{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:56:10Z","timestamp":1791446170716,"version":"4.3.3"},"reference-count":83,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"publisher","award":["LF\u2010OC\u201020\u2010000418"],"award-info":[{"award-number":["LF\u2010OC\u201020\u2010000418"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) has been associated with microbial gut dysbiosis in children. Data in adults is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to explore the fecal microbiome composition in AD patients versus healthy controls (HC) and investigate the impact of environmental aspects such as the geographical location and dietary habits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this case control study, a total of 140 fecal samples from 69\n                      <jats:sc>AD<\/jats:sc>\n                      patients and 71 HC from Tanzania (TZ) and Switzerland (CH) were analyzed. Illumina shotgun metagenomics sequencing was performed followed by taxonomic profiling, calculation of alpha\/beta diversity, and permutational multivariate analysis of variance. Differentially abundant species and genera between AD and HC were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Alpha diversity (Shannon Index) did not significantly differ between AD and HC. The presence of AD was identified as a significant source of fecal microbiome variation (Bray\u2013Curtis beta diversity). On the species level,\n                      <jats:italic>Faecalibacterium taiwanense<\/jats:italic>\n                      was more abundant in AD, and\n                      <jats:italic>Vescimonas sp000435555<\/jats:italic>\n                      in HC. On the genus level, CAG\u2010302 (NCBI: Clostridium) was more abundant in HC. Geographical location was associated with distinct dietary habits.\n                      <jats:italic>Prevotella<\/jats:italic>\n                      was significantly more abundant in TZ, whereas\n                      <jats:italic>Alistipes<\/jats:italic>\n                      and\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      were significantly more abundant in CH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of AD significantly impacted the fecal microbiome variation and was associated with a particular microbial composition. The impact of geographical location on the fecal microbiome may be related to nutritional differences. Our data support the rationale of a gut\u2010skin axis and pave the way towards therapeutic approaches modulating the microbiome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70459","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:23:18Z","timestamp":1785241398000},"page":"3584-3598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Habits and Atopic Dermatitis Significantly Influence the Fecal Microbiome"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-3662","authenticated-orcid":false,"given":"Danielle","family":"Fehr","sequence":"first","affiliation":[{"name":"Allergy Unit, Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education  Davos 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