{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:55:39Z","timestamp":1791446139250,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Atopic dermatitis (AD) is characterized by microbial dysbiosis, notably an overabundance of\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      species. This study aimed to evaluate the effects of abrocitinib, a Janus kinase 1\u2010selective inhibitor, on the skin microbiome and clinical outcomes in patients with moderate\u2010to\u2010severe AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients enrolled in JADE MOA (NCT03915496) were randomly assigned to receive once\u2010daily abrocitinib (100 or 200\u2009mg) or placebo for 12\u2009weeks. Skin swabs collected at baseline and Weeks 2, 4, and 12 underwent 16S rRNA gene amplicon sequencing to determine microbial composition. Disease severity was assessed at the same time points using established clinical metrics. Associations between microbial abundance and clinical metrics, as well as inflammatory and skin barrier markers, were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 43 patients were included. Alpha diversity increased significantly at Week 12 of treatment with abrocitinib 200\u2009mg. Beta diversity analysis revealed clustering of the abrocitinib groups away from placebo as early as Week 2; divergence continued through Week 12.\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>S. aureus<\/jats:italic>\n                      <\/jats:styled-content>\n                      relative abundance decreased in a dose\u2010dependent manner from Week 2 through Week 12 of abrocitinib treatment. Changes in skin microbial composition corresponded with improvements in clinical metrics of disease severity as well as immune markers of AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Abrocitinib treatment is associated with beneficial changes in the skin microbiome, notably a reduction in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>S. aureus<\/jats:italic>\n                      <\/jats:styled-content>\n                      and increased microbial diversity. These findings provide insight into the mechanism of action of abrocitinib and the interplay of immunomodulation and the skin microbiome in AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT03915496\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT03915496\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70467","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:20:25Z","timestamp":1785684025000},"page":"3599-3607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Abrocitinib on the Skin Microbiome in Patients With Moderate\u2010to\u2010Severe Atopic Dermatitis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-3631","authenticated-orcid":false,"given":"Madeline","family":"Kim","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-8536","authenticated-orcid":false,"given":"Ester","family":"Del Duca","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-1976","authenticated-orcid":false,"given":"Joel","family":"Correa Da Rosa","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-3940","authenticated-orcid":false,"given":"Juliana","family":"Pulsinelli","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-6747","authenticated-orcid":false,"given":"Yeriel","family":"Estrada","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Chan","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allshine","family":"Chen","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erman","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Page","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman\u2010Yassky","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100001\u2010z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19125"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.131029.111"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155\u20109899.1000110"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.04.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15969"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713460"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2010.09892.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.5.593"},{"key":"e_1_2_10_14_1","volume-title":"Euroguiderm Guideline on Atopic Eczema","author":"Wollenberg A.","year":"2022"},{"key":"e_1_2_10_15_1","unstructured":"Pfizer Inc \u201cCIBINQO (Abrocitinib) Tablets for Oral Use \u201d Prescribing Information. New York NY (2022) https:\/\/cdn.pfizer.com\/pfizercom\/USPI_Med_Guide_CIBINQO_Abrocitinib_tablet.pdf."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.022"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.05.024"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15742"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2021.13.5.762"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071487"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2025.07.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.11.047"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100209\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.03006\u201005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8986.2"},{"key":"e_1_2_10_27_1","first-page":"235","article-title":"Phyloseq: A Bioconductor Package for Handling and Analysis of High\u2010Throughput Phylogenetic Sequence Data","volume":"2012","author":"McMurdie P. 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