{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:07:54Z","timestamp":1789186074755,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102024\u201000403700"],"award-info":[{"award-number":["RS\u20102024\u201000403700"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phenotype\u2010based asthma classification has limitations that have motivated endotype\u2010based approaches grounded in pathophysiology. However, existing biomarkers offer limited specificity and clinical accessibility. Plasma metabolomics, which reflects disease\u2010specific metabolic states, offers a promising strategy for asthma classification. This study aimed to identify metabolic subgroups (metabotypes) of adult asthma using plasma metabolomics, with potential implications for personalized treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma samples from 407 patients with asthma in the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) were analyzed using Biocrates AbsoluteIDQ p400 HR kit with liquid chromatography\u2010mass spectrometry. After preprocessing, 281 metabolites were natural\u2010log\u2010transformed, standardized, and partitioned by k\u2010means clustering. The number of clusters was determined by a multi\u2010criteria assessment combining cluster validity indices, consensus clustering, stability analysis, and cross\u2010algorithm agreement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four metabotypes with distinct lipid\u2010class signatures were identified. Group 1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009123) was characterized by elevated ether\u2010linked phosphatidylcholines, comprising younger patients with the earliest symptom onset and female predominance. Group 2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953) showed elevated lyso\u2010phosphatidylcholines and altered amino acid metabolism (elevated glutamate, reduced glutamine), representing a metabolically intermediate, non\u2010T2\u2010high subgroup. Group 3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009158) exhibited globally reduced sphingomyelins and broadly lower phosphatidylcholines in middle\u2010aged, non\u2010obese patients. Group 4 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200973) showed markedly elevated triacylglycerols (TG) and diacylglycerols (DG) with the highest body mass index (BMI), consistent with a non\u2010T2, obesity\u2010related metabotype. The TG\/DG signature of Group 4 remained robust after adjustment for BMI, age, and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma metabolomics identifies clinically meaningful asthma metabotypes, supporting integration of metabolomic profiling into personalized asthma management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70469","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:33:22Z","timestamp":1785926002000},"page":"3318-3327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Metabolomes Identify Distinct Asthma Metabotypes: Findings From the\n                    <scp>COREA<\/scp>\n                    Cohort"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-1504","authenticated-orcid":false,"given":"Woori","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"},{"name":"Kidney Research Institute Seoul National University Medical Research Center  Seoul Republic of Korea"},{"name":"Korea Bioinformation Center Korea Research Institute of Bioscience and Biotechnology  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-2660","authenticated-orcid":false,"given":"Jin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine, College of Medicine Kyung Hee University Hospital at Gangdong, Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-8140","authenticated-orcid":false,"given":"Chae Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9834-6531","authenticated-orcid":false,"given":"Seo\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-1497","authenticated-orcid":false,"given":"Eunse","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-997X","authenticated-orcid":false,"given":"Hyouk\u2010Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-9922","authenticated-orcid":false,"given":"Woo\u2010Jung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8767-2667","authenticated-orcid":false,"given":"You Sook","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-8273","authenticated-orcid":false,"given":"Joo\u2010Youn","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"},{"name":"Kidney Research Institute Seoul National University Medical Research Center  Seoul Republic of Korea"},{"name":"Department of Biomedical Sciences Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-0640","authenticated-orcid":false,"given":"Tae\u2010Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Global Strategy for Asthma Management and Prevention","author":"Lung NH, Institute B","year":"1995"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8712-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.037"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.979"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.969243"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/354671"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500736"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01740-2016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081\u20101206(10)60530\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2018.08.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202010-1249OC"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2021.100547"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.12.024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2741\/4474"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010022\u201001677\u20104"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20103525"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2012.02855.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139810"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116170"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00077205"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1971973"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010025\u201003175\u2010x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.51611"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005765"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12489"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108977\u20109\u201048"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27430"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111564"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.008"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:23:18Z","timestamp":1789183398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/all.70469"],"URL":"https:\/\/doi.org\/10.1111\/all.70469","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}