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This study aimed to classify FA trajectories and examine differences in placental DNA methylation and serum cytokine profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1518 children from the COCOA (COhort for Childhood Origin of Asthma and Allergic Diseases) study, followed until age 7, were classified into FA trajectories using group\u2010based trajectory modeling. Serum cytokine levels were measured at ages 3 and 7\u2009years. Placental methylation profiling was performed with Infinium MethylationEPIC BeadChip.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children were classified into four trajectories: no FA (87.3%), early remission (6.9%), early persistent (4.6%), and late remission (1.1%). At ages 3 and 7, the early persistent FA trajectory exhibited higher interleukin (IL)\u20104, IL\u20105, and IL\u20106 levels than the no FA trajectory. At age 3, IL\u201010 levels were lower in the early persistent trajectory than in the late remission trajectory. In DNA methylation analysis, the Ribosomal Protein S6 Kinase A2 (RPS6KA2) and Germinal Center Associated Signaling And Motility Like (GCSAML) genes were significantly hypermethylated in the early persistent FA trajectory compared to the no FA and early remission trajectory (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). GCSAML methylation was positively correlated with total IgE, egg white\u2013specific IgE, early\u2010life eosinophils, and IL\u20105 at age 7 (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypermethylation of RPS6KA2 and GCSAML, reduced IL\u201010 levels, and elevated Th2 cytokines were associated with early persistent FA trajectory, potentially influencing its allergic inflammation and persistence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70471","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:54:14Z","timestamp":1787198054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental Epigenetic Alterations and\n                    <scp>IL<\/scp>\n                    \u201010 Dysregulation Drive Early Persistent Food Allergy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-1592","authenticated-orcid":false,"given":"Eom Ji","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Pediatrics CHA Gangnam Medical Center, CHA University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-0318","authenticated-orcid":false,"given":"Seung Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Sciences University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-9445","authenticated-orcid":false,"given":"Si Hyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Sciences University of Ulsan College 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