{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:56:12Z","timestamp":1791446172190,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG2668"],"award-info":[{"award-number":["RTG2668"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1021"],"award-info":[{"award-number":["SFB 1021"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 309"],"award-info":[{"award-number":["KFO 309"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SK 317\/1\u20101"],"award-info":[{"award-number":["SK 317\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031239","name":"Universities of Giessen and Marburg Lung Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008662","name":"Joachim Herz Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Preschool wheeze is heterogeneous and only a subset of children progresses to persistent asthma. We hypothesized that early\u2010life wheeze reflects divergent airway epithelial maturation trajectories associated with distinct mucosal immune programs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Nasal epithelial transcriptomes from 265 children and young adults (79 healthy, 81 wheezers, 105 asthmatics; median age 10.4 [1.1\u201320.3] years) from the All Age Asthma Cohort (ALLIANCE) cohort were analyzed using a hypothesis\u2010driven candidate approach based on predefined cytokine axes. Transcriptional signatures were mapped to epithelial cells by scRNA\u2010sequencing. Asthma\u2010outcome associations were assessed in age\u2010 and sensitization\u2010adjusted multivariate models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The candidate approach identified three antagonistic epithelial immune programs: an interferon\u2010associated (E1; IDO1, CSF3, CCL20), a type\u20102\u2010associated (E2; POSTN, CCL26, CST1), and a type\u201017\u2010associated program (E3; IL36G, KLK7, KRTDAP). These programs were detected across basal, ciliated, and secretory epithelial cells. In early childhood (1\u20133\u2009years), wheezers predominantly exhibited E1\/E3\u2010dominant epithelial profiles (\n n<\/jats:italic>\n \u2009=\u200936). Age\u2010group\u2010specific comparisons showed higher E2 and lower E1\/E3 expression in wheezers aged 4\u20136\u2009years (\n n<\/jats:italic>\n \u2009=\u200938) than in those aged 1\u20133\u2009years (\n n<\/jats:italic>\n \u2009=\u200936). E2 dominance correlated with IgE, FeNO, and eosinophilia (\n p<\/jats:italic>\n \u2009<\u20090.01). In multivariate models assessing asthma outcome at age 6, E1 expression was inversely associated with asthma persistence (OR\u2009=\u20090.15,\n p<\/jats:italic>\n \u2009<\u20090.05), whereas E3 expression was associated with disease progression (OR\u2009=\u20094.93,\n p<\/jats:italic>\n \u2009<\u20090.05). The combined epithelial signature discriminated asthma outcomes with high accuracy (AUC\u2009=\u20090.90), independent of allergic sensitization.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Early\u2010life wheeze reflects distinct airway epithelial immune programs characterized by age\u2010associated patterns in epithelial immune activity. Nasal epithelial transcriptional signatures capture molecular trajectories associated with asthma persistence and may enable early risk stratification.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n All\u2010Age\u2010Asthma (ALLIANCE) cohort:\n clinicaltrials.gov<\/jats:ext-link>\n : NCT02496468; adult arm: NCT02419274\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.70477","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:38:03Z","timestamp":1788763083000},"page":"3533-3553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nasal Epithelial Immune Signatures Are Associated With Age\u2010Dependent Asthma Trajectories in Early Life"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-0393","authenticated-orcid":false,"given":"Constanze A.","family":"Jakwerth","sequence":"first","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Illi","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Institute for Asthma and Allergy Prevention (IAP), Helmholtz Munich, German Research Center for Environmental Health (GmbH) Munich Germany"},{"name":"Comprehensive Pneumology Center \u2013 Munich (CPC\u2010M) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Charles","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlen","family":"Oelsner","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr A.","family":"Gabr","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich M.","family":"Zissler","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Erb","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Feuerherd","sequence":"additional","affiliation":[{"name":"Helmholtz Munich Munich Germany"},{"name":"Institute of Virology, School of Medicine and Health Technical University of Munich Munich Germany"},{"name":"German Center for Infection Research (DZIF), Munich Partner Site Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Drost","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology Helmholtz Munich\u2014German Research Center for Environmental Health Neuherberg Germany"},{"name":"School of Life Sciences Weihenstephan Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology Helmholtz Munich\u2014German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Schubert","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Institute of Computational Biology Helmholtz Munich\u2014German Research Center for Environmental Health Neuherberg Germany"},{"name":"Department of Mathematics Technical University of Munich Garching bei M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-4218","authenticated-orcid":false,"given":"Nicole","family":"Maison","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Institute for Asthma and Allergy Prevention (IAP), Helmholtz Munich, German Research Center for Environmental Health (GmbH) Munich Germany"},{"name":"Comprehensive Pneumology Center \u2013 Munich (CPC\u2010M) Munich Germany"},{"name":"Department of Pulmonary and Allergy, Dr von Hauner Children's Hospital, University Children's Hospital Ludwig Maximilians University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Omony","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Institute for Asthma and Allergy Prevention (IAP), Helmholtz Munich, German Research Center for Environmental Health (GmbH) Munich Germany"},{"name":"Comprehensive Pneumology Center \u2013 Munich (CPC\u2010M) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-979X","authenticated-orcid":false,"given":"Markus","family":"Weckmann","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases Research Center Borstel\u2010Leibniz Lung Center Borstel Germany"},{"name":"Division of Pediatric Pneumology and Allergology, University Children's Hospital L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"Airway Research Center North (ARCN) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Grychtol","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Department of Paediatric Pneumology, Allergology and Neonatology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Maria","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Department of Paediatric Pneumology, Allergology and Neonatology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Foth","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg Marburg Germany"},{"name":"University Children's Hospital Marburg, University of Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthi","family":"Skevaki","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics University of Marburg Marburg Germany"},{"name":"University of Gie\u00dfen, Marburg Lung Center (UGMLC) Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Trojan","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"van Koningsbruggen\u2010Rietschel","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Hansen","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Department of Paediatric Pneumology, Allergology and Neonatology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Hannover Germany"},{"name":"Cluster of Excellence RESIST (EXC 2155) Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bahmer","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Airway Research Center North (ARCN) Germany"},{"name":"Internal Medicine Department I University Hospital Schleswig\u2010Holstein \u2010 Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus F.","family":"Rabe","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Airway Research Center North (ARCN) Germany"},{"name":"LungenClinic Grosshansdorf GmbH and Medical Clinics Christian Albrechts University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases Research Center Borstel\u2010Leibniz Lung Center Borstel Germany"},{"name":"Division of Pediatric Pneumology and Allergology, University Children's Hospital L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"Airway Research Center North (ARCN) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias Volkmar","family":"Kopp","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pneumology and Allergology, University Children's Hospital L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"Airway Research Center North (ARCN) Germany"},{"name":"University Children's Hospital, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Protzer","sequence":"additional","affiliation":[{"name":"Helmholtz Munich Munich Germany"},{"name":"Institute of Virology, School of Medicine and Health Technical University of Munich Munich Germany"},{"name":"German Center for Infection Research (DZIF), Munich Partner Site Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Chaker","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Department of Otorhinolaryngology, TUM School of Medicine and Health, Klinikum rechts der Isar Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Schaub","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Comprehensive Pneumology Center \u2013 Munich (CPC\u2010M) Munich Germany"},{"name":"Department of Pulmonary and Allergy, Dr von Hauner Children's Hospital, University Children's Hospital Ludwig Maximilians University Munich Germany"},{"name":"German Center for Child & Adolescent Health (DZKJ) Dr v Hauner Children's Hospital, LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-4515","authenticated-orcid":false,"given":"Erika","family":"von Mutius","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL) Germany"},{"name":"Institute for Asthma and Allergy Prevention (IAP), Helmholtz Munich, German Research Center for Environmental Health (GmbH) Munich Germany"},{"name":"Comprehensive Pneumology Center \u2013 Munich (CPC\u2010M) Munich Germany"},{"name":"Department of Pulmonary and Allergy, Dr von Hauner Children's Hospital, University Children's Hospital Ludwig Maximilians University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-8084","authenticated-orcid":false,"given":"Carsten B.","family":"Schmidt\u2010Weber","sequence":"additional","affiliation":[{"name":"School of Medicine and Health, Center of Allergy and Environment (ZAUM) Technical University of Munich Munich Germany"},{"name":"Helmholtz Munich Munich Germany"},{"name":"Member of the German Center for Lung Research (DZL) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ALLIANCE Study Group as part of the German Center for Lung Research (DZL)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0347-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211592"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.038"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00974"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02327-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202305-0934OC"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0295OC"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9812110"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02288-2021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30466-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.110"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06721-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.02.040"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.06.025"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02135-2016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.07.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.050"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201603-0526LE"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84910"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04345-x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123163"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062211"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0705-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"e_1_2_10_27_1","unstructured":"German Medical Association (B\u00c4K) NAoSHIPK Working Group of Scientific Medical Societies (AWMF) \u201cNationale VersorgungsLeitlinie Asthma \u2013 Langfassung 4. Auflage\u201d[National Asthma Care Guideline \u2013 Long Version] Version 1 (2020)."}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:32:16Z","timestamp":1791444736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/all.70477"],"URL":"https:\/\/doi.org\/10.1111\/all.70477","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}