{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:20:19Z","timestamp":1787898019135,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01\u2010ES102906"],"award-info":[{"award-number":["Z01\u2010ES102906"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most peanut allergic patients have antibodies to Ara h 1. Many studies have focused on the C\u2010terminal vicilin region, with less attention concentrated on the N\u2010terminal \u03b1\u2010hairpinin domain. This study evaluated human monoclonal antibodies targeted to both regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Microarrays of Ara h 1 peptides were probed for serum IgE binding. Human monoclonal antibodies to Ara h 1 were discovered from single\u2010cell sequencing and hybridoma technologies. Western blots evaluated the cleavage pattern of Ara h 1 in peanuts. A mouse model of passive systemic anaphylaxis (PSA) evaluated the functional coupling of antibodies. ELISAs established antibody specificities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 75 allergic patients, the most frequently recognized peptides from Ara h 1 were in the unstructured region (91%), the \u03b1\u2010hairpinin (86%), and the vicilin region (79%). Monoclonal antibodies were divided by specificity for the \u03b1\u2010hairpinin and vicilin regions with no significant cross\u2010reactivity observed. The anti\u2010\u03b1\u2010hairpinin mAb 40C7 blocked 55%\u201392% of patient IgE to the domain in seven patients; ELISA results showed the epitope of 40C7 was associated with a frequently recognized peptide found via microarray. Pairing of anti\u2010\u03b1\u2010hairpinin mAbs failed to induce anaphylaxis via PSA; however, a single mAb against the vicilin region induced anaphylaxis when challenged with nAra h 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The \u03b1\u2010hairpinin of Ara h 1 contains a dominant epitope that is both frequently recognized and blocks a majority of the IgE against this domain. Including this region in tests may improve diagnosis of peanut allergy. The trimeric structure of the vicilin region explains the ability of Ara h 1 to induce anaphylaxis with a single antibody.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70495","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:58:08Z","timestamp":1787896688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human\n                    <scp>IgE<\/scp>\n                    Antibodies Recognize the Vicilin and Alpha\u2010Hairpinin Domains of Peanut Allergen Ara h 1"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7955-5988","authenticated-orcid":false,"given":"Taylor M.","family":"Cosey","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-0370","authenticated-orcid":false,"given":"Gage O.","family":"Leighton","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel R.","family":"De Diavoukana","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8265-5307","authenticated-orcid":false,"given":"Min","family":"Shi","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-2085","authenticated-orcid":false,"given":"Alexander C. Y.","family":"Foo","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8729-1829","authenticated-orcid":false,"given":"Anna","family":"Pom\u00e9s","sequence":"additional","affiliation":[{"name":"InBio  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline B.","family":"Nesbit","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture Agricultural Research Service  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5173-3309","authenticated-orcid":false,"given":"Stephen A. Y.","family":"Gipson","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture Agricultural Research Service  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Creeks","sequence":"additional","affiliation":[{"name":"IgGenix  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-7875","authenticated-orcid":false,"given":"R. Stokes","family":"Peebles","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-9958","authenticated-orcid":false,"given":"Soheila J.","family":"Maleki","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture Agricultural Research Service  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-1865","authenticated-orcid":false,"given":"Derek","family":"Croote","sequence":"additional","affiliation":[{"name":"IgGenix  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-8662","authenticated-orcid":false,"given":"Scott A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8361-5323","authenticated-orcid":false,"given":"Geoffrey A.","family":"Mueller","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1398-9995.2010.02346.x","article-title":"Prevalence and Distribution of Sensitization to Foods in the European Community Respiratory Health Survey: A EuroPrevall Analysis","volume":"65","author":"Burney P.","year":"2010","journal-title":"Allergy"},{"issue":"23","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1056\/NEJMc1713844","article-title":"Food Allergy","volume":"377","author":"Jones S. 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