{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:10:47Z","timestamp":1788757847700,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016\u201003086"],"award-info":[{"award-number":["2016\u201003086"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017\u201002529"],"award-info":[{"award-number":["2017\u201002529"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018\u201002524"],"award-info":[{"award-number":["2018\u201002524"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201001060"],"award-info":[{"award-number":["2019\u201001060"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201002170"],"award-info":[{"award-number":["2020\u201002170"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2024\u201003164"],"award-info":[{"award-number":["2024\u201003164"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det f\u00f6r h\u00e4lsa, arbetsliv och v\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2017\u201000526"],"award-info":[{"award-number":["2017\u201000526"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2016\u201001646"],"award-info":[{"award-number":["2016\u201001646"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term prognosis of childhood asthma remains uncertain. We aimed to (1) assess the prevalence of asthma remission from childhood to young adulthood, (2) identify associated factors, and (3) evaluate whether symptom\u2010based remission was related to objective markers of inflammation and lung function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed data from 2698 participants in the Swedish population\u2010based BAMSE birth cohort, followed up to age 24\u2009years with questionnaires and clinical examinations. Symptom\u2010based remission was defined as absence of asthma symptoms and medication in the preceding year. Clinical remission also required no hospital visits and optimization of lung function (postbronchodilator forced expiratory volume in 1\u2009s \u2265\u200980%). Complete remission required normal eosinophil counts (&lt;\u20090.3\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) and fractional exhaled nitric oxide levels (&lt;\u200940\u2009ppb).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 257 participants with asthma at age 8\u2009years, 39% achieved symptom\u2010based remission, 29% clinical remission, and 18% complete remission at age 24\u2009years. Male sex increased the likelihood of symptom\u2010based remission (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.3\u20134.5), whereas food sensitization (OR 0.3, 95% CI 0.3\u20130.6) and overweight\/obesity (OR 0.4, 95% CI 0.2\u20130.9) decreased it. Among individuals in symptom\u2010based remission, 27% displayed abnormal results in at least one objective marker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Four of 10 participants with asthma in childhood achieved symptom\u2010based remission by young adulthood, but rates declined when stricter, objective definitions were applied. A substantial subset of individuals with symptom\u2010based remission still showed signs of type two inflammation or reduced lung function, indicating that absence of symptoms does not necessarily reflect complete disease resolution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70496","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:20:40Z","timestamp":1788754840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asthma Remission From Childhood to Young Adulthood\u2013A Population\u2010Based Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-5749","authenticated-orcid":false,"given":"Lina","family":"Brostr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet  Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-6314","authenticated-orcid":false,"given":"Anna","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Centre for Occupational and Environmental Medicine Region Stockholm  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Merritt","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Centre for Occupational and Environmental Medicine Region Stockholm  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-4647","authenticated-orcid":false,"given":"Maria","family":"\u00d6dling","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-0663","authenticated-orcid":false,"given":"Erik","family":"Mel\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet  Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-3771","authenticated-orcid":false,"given":"Inger","family":"Kull","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet  Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-8190","authenticated-orcid":false,"given":"Sandra","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet  Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Centre for Occupational and Environmental Medicine Region Stockholm  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global Strategy for Asthma Management and Prevention: GINA Executive Summary","volume":"31","author":"Bateman E. 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