{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:55:39Z","timestamp":1791446139342,"version":"4.3.3"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["324S425"],"award-info":[{"award-number":["324S425"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019412","name":"Bursa Uluda\u011f \u00dcniversitesi","doi-asserted-by":"publisher","award":["TGA3\u20102024\u20102015"],"award-info":[{"award-number":["TGA3\u20102024\u20102015"]}],"id":[{"id":"10.13039\/100019412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anaphylaxis is classically framed around IgE\u2010Fc\u03b5RI, yet a subset of severe reactions engages an IgG\u2013Fc\u03b3R\u2010mediated arm whose consequences for mucosal barrier integrity and epithelial repair remain undefined under recurrence. We propose that mucosal surfaces sustain function during severe anaphylaxis through coordinated operation of immunological composition, structural integrity and reparative capacity\u2014which we term mucosal allostasis\u2014and asked whether the two pathways diverge along this framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BALB\/c mice were resolved into IgE\u2010 and IgG\u2010mediated arms using a hybrid active\/passive (ASA\u2010PSA) sensitisation model and subjected to acute or recurrent severe anaphylaxis, with pharmacological reversal enabling matched rechallenge. Lung, small intestine, colon and serum were profiled across cytokine, mediator, junctional, repair and bacterial 16S rDNA panels; ILC subsets and junctional integrity were resolved by flow cytometry and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Despite comparable systemic clinical severity, the two pathways diverged sharply at the mucosal level. IgE\u2010mediated recurrence preserved junctional expression and mounted a coordinated AREG\/EGF\/periostin\/TFF3\/MUC2 repair programme, whereas IgG\u2010mediated recurrence dismantled both: Claudin\u20101, Occludin, ZO\u20101 and E\u2010cadherin declined in tissue and rose reciprocally in serum, repair mediators failed to engage where junctional injury was greatest, and bacterial DNA translocation rose 48\u2010fold, alongside a type 2\/regulatory to inflammatory shift and an ILC2 to ILC1\/NCR\n                      <jats:sup>+<\/jats:sup>\n                      ILC3 reorganisation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Recurrent IgE\u2010 and IgG\u2010mediated severe anaphylaxis diverge into two mechanistically opposite allostatic phenotypes. IgG\u2010mediated recurrence produces an allostatic collapse in which structural failure proceeds uncoupled from reparative engagement, identifying barrier\u2013repair coupling as a candidate axis for intervention in refractory anaphylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70503","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:21:59Z","timestamp":1788254519000},"page":"3673-3694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Failed Mucosal Allostasis Distinguishes Murine\n                    <scp>IgG<\/scp>\n                    \u2010 From\n                    <scp>IgE<\/scp>\n                    \u2010Mediated Recurrent Severe Anaphylaxis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-0269","authenticated-orcid":false,"given":"Abdurrahman","family":"Simsek","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-7911","authenticated-orcid":false,"given":"Muhammed Ali","family":"Kizmaz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University  Bursa Turkey"},{"name":"Department of Biotechnology and Genetics Mudanya University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-8716","authenticated-orcid":false,"given":"Tugce","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University  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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-7917","authenticated-orcid":false,"given":"Ahmet","family":"Akkoc","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Bursa Uluda\u011f University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-4293","authenticated-orcid":false,"given":"Dane","family":"Ediger","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Chest Diseases, Faculty of Medicine Bursa Uludag University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7625-9148","authenticated-orcid":false,"given":"Ferah Budak","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Bursa Uluda\u011f University  Bursa 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