{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:15:01Z","timestamp":1788506101528,"version":"build-2803163510"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Atopic dermatitis (AD) is characterized by pruritus, epidermal hyperplasia, and lichenification that significantly impairs quality of life. Nemolizumab, an anti\u2013IL\u201031R\u03b1 monoclonal antibody, is approved for treating moderate\u2010to\u2010severe AD in patients aged >\u200912\u2009years. This study investigated nemolizumab's molecular mechanisms using patient samples from the ARCADIA 1 (NCT03985943) and 2 (NCT03989349) trials.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Tape\u2010strips were collected from the lesional and non\u2010lesional skin of 71 nemolizumab\u2010treated and 39 placebo\u2010treated patients, all receiving background topical corticosteroids \u00b1 topical calcineurin inhibitors, at baseline and after 16\u2009weeks of treatment for bulk RNAseq analysis. Single cell RNAseq was performed on a subset of untreated patients and used as a reference to map bulk RNA\u2010seq DEGs, providing cellular context for treatment\u2010associated transcriptional changes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Bulk RNAseq revealed significant transcriptomic modulation following 16\u2009weeks of nemolizumab treatment (797 downregulated\/142 upregulated genes), while placebo\u2010treated patients showed minimal changes. Nemolizumab treatment attenuated expression of pruritus\u2010related genes (e.g.,\n OSMR<\/jats:italic>\n ,\n TRPV3<\/jats:italic>\n ,\n HRH1<\/jats:italic>\n ,\n KLK6\/7\/9<\/jats:italic>\n ) and genes involved in epidermal hyperplasia and ECM remodeling (e.g.,\n COL1A1\/12A1<\/jats:italic>\n ,\n IGFBP3<\/jats:italic>\n ). Inflammatory pathways were also modulated, with downregulation of Th17\u2010 and Th1\u2010related genes (e.g.,\n S100A7\/8\/9<\/jats:italic>\n ,\n PI3<\/jats:italic>\n ,\n MX1<\/jats:italic>\n ,\n OASL<\/jats:italic>\n ). Pathway\u2010level analysis demonstrated normalization of pruritus and inflammatory gene signatures, including Th2 and Th22 pathways. Subgroup analysis showed that patients with severe baseline pruritus (PPNRS \u2265\u20097) had higher baseline expression of immune\u2010related genes and experienced greater downregulation following treatment compared to patients with moderate baseline itch. Single\u2010cell mapping of differentially expressed genes suggested enrichment of these genes in keratinocyte, fibroblast, endothelial, and nerve cell subpopulations. Clinically, improvements in EASI and pruritus scores (PPNRS) correlated with decreased expression of fibrosis\u2010 and pruritus\u2010associated genes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings provide molecular evidence supporting nemolizumab's therapeutic efficacy across multiple disease domains, including pruritus, inflammation, and epidermal hyperplasia, highlighting its role in AD treatment and management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.70505","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:09:47Z","timestamp":1788505787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tape Strip Transcriptomics Reveal Nemolizumab Effects on Pruritus, Hyperplasia, Inflammation, and Extracellular Matrix Markers in Patients With Moderate\u2010to\u2010Severe Atopic Dermatitis"],"prefix":"10.1111","author":[{"given":"Daniel","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-8536","authenticated-orcid":false,"given":"Ester Del","family":"Duca","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Delaleu","sequence":"additional","affiliation":[{"name":"Galderma Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-3940","authenticated-orcid":false,"given":"Juliana","family":"Pulsinelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-1976","authenticated-orcid":false,"given":"Joel Correa","family":"de Rosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeriel","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-0812","authenticated-orcid":false,"given":"Johann","family":"Gudjonsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Julia","sequence":"additional","affiliation":[{"name":"Galderma Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman\u2010Yassky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai Mount Sinai New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjd.19580","article-title":"The Global Burden of Atopic Dermatitis: Lessons From the Global Burden of Disease Study 1990\u20132017","volume":"184","author":"Laughter M. 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