{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:26:00Z","timestamp":1794029160204,"version":"4.8.0"},"reference-count":79,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010NR069576"],"award-info":[{"award-number":["RS\u20102022\u2010NR069576"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000348170"],"award-info":[{"award-number":["RS\u20102024\u201000348170"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022M3A9D3016848"],"award-info":[{"award-number":["2022M3A9D3016848"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001866"],"award-info":[{"award-number":["UL1 TR001866"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) and psoriasis (PsO) are chronic inflammatory skin diseases with distinct features, but clinical and molecular overlap exists. These ambiguous phenotypes complicate diagnosis and treatment, and their immunologic basis remains poorly defined. This study aimed to delineate compartment\u2010specific immune profiles in AD\u2010PsO overlap lesions and explore candidate markers associated with molecular stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Spatial transcriptomic profiling (GeoMx) was performed on 14 biopsies (AD\u2009=\u20094, PsO\u2009=\u20094, clinically ambiguous AD\u2010PsO overlap\u2009=\u20096), followed by immunohistochemical (IHC) analysis of candidate markers in an expanded cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935; AD\u2009=\u20099, PsO\u2009=\u20099, overlap\u2009=\u200917) to support the transcriptomic findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AD\u2010PsO overlap lesions demonstrated intermediate Th2 and Th17 signatures relative to AD and PsO and showed relative alignment toward AD\u2010like or PsO\u2010like molecular patterns rather than forming a single uniform state. Patient\u2010level analyses showed distinct pathway profiles, with AD\u2010like alignment associated with epidermal barrier\u2010related pathways and dermal neural\/sensory signaling, whereas the PsO\u2010like alignment was associated with Th1, Th17, interferon, IL\u201015, and neutrophil\u2010related pathways. Candidate genes associated with AD\u2010like alignment included\n                      <jats:italic>CCL13<\/jats:italic>\n                      ,\n                      <jats:italic>CCL19<\/jats:italic>\n                      ,\n                      <jats:italic>P2RY4<\/jats:italic>\n                      ,\n                      <jats:italic>CXCR4<\/jats:italic>\n                      ,\n                      <jats:italic>IL4I1<\/jats:italic>\n                      , and\n                      <jats:italic>EBI3<\/jats:italic>\n                      , whereas\n                      <jats:italic>MAVS<\/jats:italic>\n                      and\n                      <jats:italic>C1orf43<\/jats:italic>\n                      showed relative association with PsO\u2010like alignment. IL36G, which was not used for alignment assignment, showed higher staining in PsO and PsO\u2010like overlap cases than in AD and AD\u2010like overlap cases, providing additional biological support for the observed molecular alignment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AD\u2010PsO overlap lesions are molecularly heterogeneous and align toward AD\u2010like or PsO\u2010like inflammatory patterns. Compartment\u2010resolved profiling provides a hypothesis\u2010generating framework for molecular characterization of clinically ambiguous cases that merits validation in larger independent cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70526","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:15:42Z","timestamp":1790338542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Heterogeneity in Clinically Ambiguous Atopic Dermatitis\u2013Psoriasis Overlap: Compartment\u2010Resolved Transcriptomic Profiling"],"prefix":"10.1111","author":[{"given":"Jongeun","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory for Investigative Dermatology The Rockefeller University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yookyung 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