{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:58:40Z","timestamp":1790521120706,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic Granulomatosis with Polyangiitis (EGPA), previously known as Churg\u2010Strauss syndrome, is a rare antineutrophil cytoplasmic antibody (ANCA) vasculitis, with multiorgan involvement. Due to the variable presentation, diagnosis is often challenging and delayed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to assess diagnostic delay among patients with EGPA and identify clinical characteristics associated with delayed recognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010institution retrospective chart review was performed in adult patients over 18 diagnosed with EGPA. Data was collected on demographics, clinical features, laboratory data, imaging results, biopsy results, treatment, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 36 patients were included, with an average time to diagnosis from onset of symptoms of 4.82\u2009years (SD\u2009=\u20095.44). Mean age at diagnosis was 52.5\u2009years and 47.2% were female. Overall, asthma (80.5%) and chronic rhinosinusitis (CRS) (80.5%) were the most prevalent features, and [VERIFY: abstract currently reports 5.5% CRS surgery; Results report 19\/29] of those with CRS required surgery prior to diagnosis. Lung nodules or infiltrates were identified in 77.8%, nasal polyps in 52.8%, and 27.8% had received a biologic prior to diagnosis. In this exploratory analysis, diagnostic delay &gt;\u20093\u2009years was associated with female sex (OR 6.7, 95% CI 1.66\u201331.9), elevated C\u2010ANCA (yes), which was associated with lower odds of diagnostic delay (OR 0.11, 95% CI 0.005\u20130.716,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), and prior biologic treatment (OR 7.1, 95% CI 1.42\u201354.4). Renal involvement was associated with a lower likelihood of diagnostic delay (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Given the small cohort and wide confidence intervals, these findings should be interpreted as hypothesis\u2010generating.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Diagnosing EGPA presents a clinical challenge given its rarity and multiorgan presentation. A high clinical suspicion is required to ensure earlier recognition of this rare disease, including a thorough review of systems and appropriate laboratory workup, particularly in patients with treatment\u2010resistant asthma, CRS, or eosinophilia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70528","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:32:37Z","timestamp":1790519557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Delay in Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors and Implications for Earlier Recognition"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-625X","authenticated-orcid":false,"given":"Vani","family":"Mulkareddy","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy &amp; Critical Care Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-487X","authenticated-orcid":false,"given":"Kalena","family":"Liu","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Mandloi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Limage","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-7398","authenticated-orcid":false,"given":"Samuel R.","family":"Shing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurston G.","family":"Nyquist","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5337-3498","authenticated-orcid":false,"given":"Jessica","family":"Most","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy &amp; Critical Care Thomas Jefferson University Hospital  Philadelphia Pennsylvania 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