{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:40:20Z","timestamp":1792392020419,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903236"],"award-info":[{"award-number":["81903236"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alopecia areata (AA) frequently co\u2010occurs with atopic dermatitis (AD; AA\u2010AD); however, AA\u2010AD's features remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To elucidate the clinical and immunological features of AA\u2010AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective analysis of data from 123 AA\u2010AD patients, 119 non\u2010atopic AA patients, and 126\u2009\n                      <jats:sc>AD<\/jats:sc>\n                      patients (2011\u20132024). Peripheral blood mononuclear cells (PBMCs), plasma, and scalp tissues from patients and healthy controls (HC) were examined by flow cytometry, multiplex cytokine assays, and immunofluorescence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinically, AA\u2010AD patients were younger than non\u2010atopic AA and AD\u2010only patients, showed more severe alopecia and longer duration, but milder eczema, and exhibited higher dust\u2010mite allergy, total IgE (tIgE), and Eos counts\/percentages than non\u2010atopic AA, while showing more intrinsic AD and lower tIgE and Eos counts\/percentages than AD\u2010only patients. AA severity and duration were positively correlated with those of AD. Compared with AA\u2010AD patients with AA\u2010first onset and AA with intrinsic AD (AA\u2010IAD) patients, AA\u2010AD patients with AD\u2010first onset and AA with extrinsic AD (AA\u2010EAD) patients were younger, had more severe eczema, higher tIgE levels, and dust\u2010mite allergy. Compared with the non\u2010atopic AA group and HC, the AA\u2010AD group showed elevated plasma IL\u20104\/6\/10\/13 levels and increased Th2 cells and ILC2s (group 2 innate lymphoid cells) proportions in PBMCs, along with their IL\u201013 production, all of which were positively correlated with AA course. AA\u2010AD scalp also showed that Th2 cells and ILC2s were most abundant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AA\u2010AD defines a distinct clinical\u2010immunologic endotype of AA. AA and AD exhibit an asymmetric but bilateral interaction driven by Th2\/ILC2s\u2010IL\u201013\u2010centered pathways, representing key mechanisms and targets for precision therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70534","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:46:16Z","timestamp":1792388776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of Clinical and Immunological Features of Alopecia Areata With Comorbid Atopic Dermatitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2537-5202","authenticated-orcid":false,"given":"Xin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Dermatology, the First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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