{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:23:23Z","timestamp":1789712603956,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hypotension occurs in most caesarean sections under spinal anaesthesia, necessitating vasopressor administration. However, the optimal dosing regimen remains unclear. We have developed a novel vasopressor delivery system that automatically administers phenylephrine or ephedrine based on continuous non\u2010invasive blood pressure monitoring. This prospective cohort study recruited 55 healthy women under standardised spinal anaesthesia with 2.2\u2003ml hyperbaric bupivacaine 0.5%, 15\u2003\u03bcg fentanyl and 100\u2003\u03bcg morphine. A 50\u2010\u03bcg phenylephrine bolus was given at 1\u2010min intervals when systolic blood pressure fell below 90% of baseline, and a 4\u2010mg ephedrine bolus was given when hypotension developed with bradycardia (heart rate &lt;60\u2003beats.min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Systolic blood pressure was within 20% of baseline in 88% of all measurements. Six patients (11%) had one or more measurements above 120% of baseline (1% of all measurements), whereas 36 (65%) had at least one reading below 80% of baseline (11% of total measurements). The system maintained systolic blood pressure at a mean (SD) of \u22129.1 (7.0)% below baseline, with 5.4 (2.5)% fluctuation. Two patients (4%) experienced pre\u2010delivery nausea. All 5\u2010min Apgar scores were 9.\n                  <\/jats:p>","DOI":"10.1111\/anae.12000","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T10:04:12Z","timestamp":1348999452000},"page":"1348-1355","source":"Crossref","is-referenced-by-count":33,"title":["Closed\u2010loop double\u2010vasopressor automated system to treat hypotension during spinal anaesthesia for caesarean section: a preliminary study"],"prefix":"10.1111","volume":"67","author":[{"given":"A. T. H.","family":"Sia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. L.","family":"Sng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00028"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200212000-00034"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000192816.22989.ba"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen064"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-201006121-00531"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer394"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq143"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200510000-00012"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05257.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000099782.78002.30"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e1db21"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01143186"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200604000-00006"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12000","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:47:47Z","timestamp":1761688067000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,28]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/anae.12000"],"URL":"https:\/\/doi.org\/10.1111\/anae.12000","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,28]]}}}