{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:51:33Z","timestamp":1761706293779,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Paediatric patients who require anticoagulation with therapeutic doses of low\u2010molecular weight heparin are at risk of having a residual anticoagulant effect at the time of surgery, even if managed according to current peri\u2010operative guidelines. Testing for residual effect is not currently recommended in such circumstances. A 15\u2010year\u2010old child with a mechanical aortic valve replacement requiring long\u2010term warfarin treatment, as well as underlying coagulation defects, was administered low\u2010molecular weight heparin for bridging anticoagulation before kyphoscoliosis surgery. Thromboelastography was used intra\u2010operatively to diagnose residual heparinisation, which was demonstrated by a prolonged reaction (R) time of 16.0\u2003min in the plain cup, compared with 9.2\u2003min in the heparinase cup. Subsequently, thromboelastography was also used to monitor haemostatic therapy, which consisted of protamine 2\u2003mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 500\u2003IU cryoprecipitate. Thromboelastography was used intra\u2010operatively to allow rapid testing of coagulation status and guide therapy, thereby minimising use of blood products and reducing complications.\n                  <\/jats:p>","DOI":"10.1111\/anae.12040","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T09:43:07Z","timestamp":1350034987000},"page":"91-96","source":"Crossref","is-referenced-by-count":5,"title":["Thromboelastography to monitor the intra\u2010operative effects of low\u2010molecular weight heparin following bridging anticoagulation in a child with normal renal function*"],"prefix":"10.1111","volume":"68","author":[{"given":"M. E.","family":"Casey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2291"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2298"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1160\/TH05-01-0064","article-title":"Bridging anticoagulation with low molecular weight heparin after interruption of warfarin therapy is associated with a residual anticoagulant effect prior to surgery","volume":"94","author":"Douketis JD","year":"2005","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08753.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287645.26763.be"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0675"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.04.018"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.042"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2004.00648.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05225.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200011000-00009"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef189"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05752.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-0038-1645207","article-title":"Neutralization of enoxaparine\u2010 induced bleeding by protamine sulfate","volume":"63","author":"Van Ryn\u2010 Mckenna J","year":"1990","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2308"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03964.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08163.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199508000-00026"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep098"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31822e1853"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8943"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02297.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03331.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05773.x"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:36:44Z","timestamp":1761673004000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,12]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/anae.12040"],"URL":"https:\/\/doi.org\/10.1111\/anae.12040","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"type":"print","value":"0003-2409"},{"type":"electronic","value":"1365-2044"}],"subject":[],"published":{"date-parts":[[2012,10,12]]}}}