{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:59Z","timestamp":1787013839205,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This trial aimed to compare the maternal and neonatal effects of remifentanil given by patient\u2010controlled analgesia (PCA) or continuous infusion for labour analgesia. Patient controlled analgesia was administered using increasing stepwise boluses from 0.1 to 0.4\u00a0\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    (0.1\u00a0\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    increment, 2\u00a0min lockout, n\u00a0=\u00a030). Continuous infusion used rates from 0.05 to 0.2\u00a0\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (0.05\u00a0\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .min\n                    <jats:sup>\u22121<\/jats:sup>\n                    increment, n\u00a0=\u00a030). Dose increments were given on request. Women reported lowest pain scores (median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    [range]) of 3 (2\u20134 [2\u20135]) for\n                    <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>\n                    and 4 (3\u20135.25 [3\u20137]) for continuous infusion (p\u00a0=\u00a00.004) at 60\u00a0min after the beginning of analgesia. The mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) remifentanil umbilical vein\/maternal artery ratio in the\n                    <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>\n                    and infusion groups were 0.74 (0.45) vs 0.70 (0.52), respectively (p\u00a0=\u00a00.776). The mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) umbilical artery\/umbilical vein ratios were 0.31 (0.12) vs 0.26 (0.07), respectively (p\u00a0=\u00a00.088). Maternal and neonatal adverse reactions of remifentanil were similar between the two groups. The total remifentanil consumption (median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    [range]) during\n                    <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>\n                    administration was lower than continuous infusion, 1.34 (1.22\u20131.48 [0.89\u20131.69])\u00a0mg vs 1.49 (1.35\u20131.61 [1.12\u20131.70]\u00a0mg; p\u00a0=\u00a00.011). The results suggest that remifentanil\n                    <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>\n                    provides better pain relief and similar placental transfer compared with continuous infusion.\n                  <\/jats:p>","DOI":"10.1111\/anae.12098","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T11:11:38Z","timestamp":1357557098000},"page":"236-244","source":"Crossref","is-referenced-by-count":35,"title":["Remifentanil for labour analgesia: a double\u2010blinded, randomised controlled trial of maternal and neonatal effects of patient\u2010controlled analgesia versus continuous infusion"],"prefix":"10.1111","volume":"68","author":[{"given":"M. K.","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Wuxi Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. F.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Jinlin Hospital School of Medicine Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Wuxi Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. L.","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Department of Anaesthesiology Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. F.","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine Department of Anaesthesiology Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Jinlin Hospital School of Medicine Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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