{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:31:37Z","timestamp":1788787897965,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Trendelenburg positioning in combination with pneumoperitoneum during robotic\u2010assisted prostatic surgery possibly impairs cerebrovascular autoregulation. If cerebrovascular autoregulation is disturbed, arterial hypertension might induce cerebral hyperaemia and brain oedema, while low arterial blood pressure can induce cerebral ischaemia. The time course of cerebrovascular autoregulation was investigated during use of the Trendelenburg position and a pneumoperitoneum for robotic\u2010assisted prostatic surgery using transcranial Doppler ultrasound. Cerebral blood flow velocity was correlated with arterial blood pressure and the autoregulation index (Mx) was calculated. In 23 male patients, Mx was assessed at baseline, after induction of general anaesthesia, during the Trendelenburg position (40\u201345\u00b0), and after repositioning. During the Trendelenburg position, Mx increased over time, indicating an impairment of cerebrovascular autoregulation. After repositioning, Mx recovered to baseline levels. It can be concluded that with longer durations of Trendelenburg position and pneumoperitoneum, cerebrovascular autoregulation deteriorates, and, therefore, blood pressure management should be adapted to avoid cerebral oedema and the duration of Trendelenburg position should be as short as possible.<\/jats:p>","DOI":"10.1111\/anae.12477","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T07:46:56Z","timestamp":1384933616000},"page":"58-63","source":"Crossref","is-referenced-by-count":65,"title":["Time course of cerebrovascular autoregulation during extreme Trendelenburg position for robotic\u2010assisted prostatic surgery"],"prefix":"10.1111","volume":"69","author":[{"given":"P.","family":"Schramm","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010H.","family":"Treiber","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Berres","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry, Epidemiology and Informatics (IMBEI) University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pestel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"},{"name":"RheinAhrCampus Remagen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Engelhard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Closhen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Medical Centre of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.08.491"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.007"},{"key":"e_1_2_7_4_1","first-page":"596","article-title":"Anesthetic concerns for 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