{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:39:02Z","timestamp":1791247142626,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>In thalassaemic patients, multiple organ systems may be affected by the disease, blood transfusion, iron overload and chelating therapy. Patients may develop cardiomyopathy, pulmonary hypertension or heart failure requiring pre\u2010operative echocardiography or cardiac catheterisation. Restrictive lung dysfunction is commonly encountered, especially in patients with splenomegaly. Haemoglobin level should be optimised pre\u2010operatively and maintained at adequate levels with transfusion and blood\u2010saving strategies. Susceptibility to infections should be managed with broad\u2010spectrum antibiotics. Thromboembolic events due to hypercoagulability should be prevented by simple measures, such as graduated compression stockings, intermittent pneumatic compression and early mobilisation, and possibly anticoagulant drugs. When general anaesthesia is administered, the risk of difficult intubation due to oro\u2010facial malformation should be considered. Cardiovascular depression due to negative inotropic and vasodilating effects of general anaesthesia should be minimised. Neuraxial techniques may also be challenging due to spinal skeletal abnormalities and extramedullary haemopoiesis. A multidisciplinary pre\u2010operative approach, clinical optimisation and a carefully planned strategy are mandatory.<\/jats:p>","DOI":"10.1111\/anae.12591","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T06:57:20Z","timestamp":1394089040000},"page":"494-510","source":"Crossref","is-referenced-by-count":25,"title":["A narrative review of peri\u2010operative management of patients with thalassaemia"],"prefix":"10.1111","volume":"69","author":[{"given":"C.","family":"Staikou","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Aretaieio University Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Stavroulakis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Aretaieio University Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Karmaniolou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Royal National Orthopaedic Hospital Stanmore UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2009.05.001"},{"key":"e_1_2_10_3_1","first-page":"29","article-title":"A series of cases of splenomegaly in children with anemia and peculiar bone changes","volume":"37","author":"Cooley TB","year":"1925","journal-title":"Transactions of the American Pediatric Society"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8529-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60283-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07126.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-13"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1987.11812155"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-251348"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.785"},{"key":"e_1_2_10_11_1","first-page":"157","volume-title":"The Molecular Basis of Blood Diseases","author":"Weatherall DJ","year":"1994"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511596582.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3411"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1523"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.66"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/170510"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20679"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01579.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1995-705X.99226"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00921.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09071389"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200211-1292OC"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0317"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70091-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.5.1138"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.058"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.08.004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ec0c38"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08477.x"},{"key":"e_1_2_10_31_1","first-page":"642","article-title":"Endocrine complications in patients with thalassaemia major","volume":"5","author":"Toumba M","year":"2007","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346551"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/24.1.9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.02.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296768"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.10.001"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.42"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.06.024"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0267"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283502975"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.98919"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-300335"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70437-6"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2003.11.011"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.7.2213"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00061-9"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08054.x"},{"key":"e_1_2_10_48_1","first-page":"20","article-title":"Iron overload in beta thalassemia\u2010a review","volume":"1","author":"Prabhu R","year":"2009","journal-title":"Journal of Bioscience and Technology"},{"key":"e_1_2_10_49_1","volume-title":"GeneReviews\u2122","author":"Cao A","year":"1993"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703273361318"},{"key":"e_1_2_10_51_1","first-page":"288","article-title":"Splenectomy in a patient with beta thalassemia intermedia and severe hemolytic anemia","volume":"48","author":"P\u00e9rez JA","year":"2001","journal-title":"Revista Espa\u00f1ola de Anestesiolog\u00eda y Reanimaci\u00f3n"},{"key":"e_1_2_10_52_1","first-page":"224","article-title":"Intermittent anesthesia for splenectomy and caesarean section in pregnant patient with thalassemia (case report)","volume":"17","author":"Unal Y","year":"2006","journal-title":"Gazi Medical Journal"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7533"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/39.7.585"},{"key":"e_1_2_10_55_1","first-page":"582","article-title":"Anaesthetic management of two patients with beta\u2010thalassaemia intermedia","volume":"60","author":"Ali S","year":"2010","journal-title":"Journal of the Pakistan Medical Association"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.2.288"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2005.02.002"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-005-0328-y"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129689-200310000-00006"},{"key":"e_1_2_10_60_1","first-page":"323","article-title":"Bloodless surgery in a patient with thalassemia minor. Usefulness of erythropoietin, preoperative blood donation and intraoperative blood salvage","volume":"73","author":"Perez Ferrer A","year":"2007","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000087046.91072.E8"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.79892"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.76496"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1988.tb05704.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2012.63.4.357"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2006.09.010"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199606)52:2<125::AID-AJH15>3.0.CO;2-G"},{"key":"e_1_2_10_68_1","first-page":"66","article-title":"Hypertension perioperative splenectomy in thalassemic children","volume":"77","author":"Suwanchinda V","year":"1994","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_10_69_1","first-page":"542","article-title":"Does furosemide prevent hypertension during perioperative splenectomy in thalassemic children?","volume":"78","author":"Suwanchinda V","year":"1995","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_10_70_1","first-page":"666","article-title":"Hemodynamic responses to captopril during splenectomy in thalassemic children","volume":"82","author":"Suwanchinda V","year":"1999","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1198-743x.2001.00355.x"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb48264.x"},{"key":"e_1_2_10_73_1","first-page":"365","volume-title":"Anesthesia for Genetic, Metabolic and Dysmorphic Syndromes of Childhood","author":"Baum VC","year":"2007"},{"key":"e_1_2_10_74_1","first-page":"1263","article-title":"Anesthetic management for cesarean section in a patient with hydrops foetalis","volume":"53","author":"Nishikido O","year":"2004","journal-title":"Masui"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12591","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:44:35Z","timestamp":1761669875000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/anae.12591"],"URL":"https:\/\/doi.org\/10.1111\/anae.12591","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]}}}