{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:00:05Z","timestamp":1773036005642,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We measured pre\u2010operative hepatic blood flow and postoperative morphine concentration in infants with or without biliary atresia. Thirty\u2010four infants (0\u20133\u00a0months) with biliary atresia undergoing portoenterostomy (Kasai operation) were included and hepatic blood flow was assessed by magnetic resonance imaging before surgery in 12 of them. Sixteen subjects (0\u20133\u00a0months) without liver disease undergoing abdominal or pelvic surgery acted as controls and six of them had hepatic blood flow assessed. Intravenous morphine (8\u00a0\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was administered to all patients postoperatively. The median (IQR [range]) relative hepatic blood flow was 3.51 (2.72\u20133.88 [1.68\u20134.43]) with and 3.15 (2.66\u20134.42 [2.30\u20135.01]) without biliary atresia (p\u00a0=\u00a00.851). The median (IQR [range]) morphine concentration after 24\u00a0h infusion was 5.9 (4.5\u201316.4 [2.9\u201342.2])\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 6.4 (3.2\u201312.0 [1.9\u201348.6])\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively (p\u00a0=\u00a00.460). An inverse regression relation was found between the morphine concentration and the hepatic perfusion index (R\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.519, p\u00a0=\u00a00.001). Compensatory increases in hepatic arterial blood flow maintain the total hepatic blood flow in infants with biliary atresia.\n                  <\/jats:p>","DOI":"10.1111\/anae.12624","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T06:20:29Z","timestamp":1397888429000},"page":"583-590","source":"Crossref","is-referenced-by-count":7,"title":["Postoperative morphine concentration in infants with or without biliary atresia and its association with hepatic blood flow"],"prefix":"10.1111","volume":"69","author":[{"given":"X.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. W.","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. J.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Surgery Children's Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60946-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.05.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2000.00579.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.1460-9592.2002.0810a.x-i1","article-title":"Epidural analgesia for patients undergoing hepatic portoenterostomy (Kasai procedure)","volume":"12","author":"Seffelder C","year":"2002","journal-title":"Pediatric Anesthesia"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1975184377"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059626"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.06.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.32892"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/13525061"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80215-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199310000-00007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1997.d01-30.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1899-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1213\/00000539-199805000-00008","article-title":"Clearance of morphine in postoperative infants during intravenous infusion: the influence of age and surgery","volume":"86","author":"Lynn AM","year":"1998","journal-title":"Anestheisa and Analgesia"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh042"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198702000-00005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457538"},{"key":"e_1_2_7_20_1","first-page":"972","article-title":"The maturation of morphine clearance and metabolism","volume":"146","author":"McRorie TI","year":"1992","journal-title":"The American Journal of Diseases of Children"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.127"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(93)90158-H"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70074-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50065"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31722"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20380"},{"key":"e_1_2_7_27_1","first-page":"203","volume-title":"Hepatic Circulation in Health and Disease","author":"Lautt WW","year":"1981"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.02.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i13.1598"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-008-0312-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1787-6"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:51:48Z","timestamp":1761688308000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,18]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/anae.12624"],"URL":"https:\/\/doi.org\/10.1111\/anae.12624","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,18]]}}}