{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:56Z","timestamp":1792098596778,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response that can often lead to dysfunction of major organs. We hypothesised that the highly selective \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u2010adrenergic agonist, dexmedetomidine, attenuates the systemic inflammatory response. Forty\u2010two patients were randomly assigned to receive dexmedetomidine or saline after aortic cross\u2010clamping). The mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) levels of the nuclear protein plasma high\u2010mobility group box 1 increased significantly from 5.1 (2.2)\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    during (16.6 (7.3)\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and after (14.3 (8.2)\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) cardiopulmonary bypass in the saline group. In the dexmedetomidine group, the levels increased significantly only during cardiopulmonary bypass (4.0 (1.9)\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    baseline vs 10.8 (2.7)\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) but not after (7.4 (3.8)\u00a0ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Dexmedetomidine infusion also suppressed the rise in mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) interleukin\u20106 levels after cardiopulmonary bypass (a rise of 124.5 (72.0)\u00a0pg.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs 65.3 (30.9)\u00a0pg.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). These suppressive effects of dexmedetomidine might be due to the inhibition of nuclear factor kappa B activation and suggest that intra\u2010operative dexmedetomidine may beneficially inhibit inflammatory responses associated with ischaemia\u2010reperfusion injury during cardiopulmonary bypass.\n                  <\/jats:p>","DOI":"10.1111\/anae.12636","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T08:24:42Z","timestamp":1398673482000},"page":"693-700","source":"Crossref","is-referenced-by-count":121,"title":["The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass"],"prefix":"10.1111","volume":"69","author":[{"given":"M.","family":"Ueki","sequence":"first","affiliation":[{"name":"University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Habe","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hamada","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sata","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Kitakyushu 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