{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:51:19Z","timestamp":1775195479424,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T00:00:00Z","timestamp":1400889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Hip fracture is the most common orthopaedic emergency. We investigated the concentration of 30\u00a0ml levobupivacaine that provided analgesia to 50% and 95% of patients with a hip fracture when injected around the femoral nerve under ultrasound guidance. We defined analgesia as a \u2265\u00a020\u2010point decrease on a 100\u2010point pain scale with reduced cold sensation in the middle third of the anterior thigh 30\u00a0min after the nerve block. We increased the concentration of levobupivacaine if the preceding dose had been ineffective and decreased it if the preceding dose had been effective. Probit regression modelling estimated the effective (95% CI) concentration of 30\u00a0ml levobupivacaine in 50% and 95% of patients with a fractured hip to be 0.026 (0.023\u20130.028)% w\/v and 0.036 (0.027\u20130.047)% w\/v, respectively.<\/jats:p>","DOI":"10.1111\/anae.12683","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T04:35:12Z","timestamp":1400906112000},"page":"683-686","source":"Crossref","is-referenced-by-count":14,"title":["Femoral nerve block for pain relief in hip fracture: a dose finding study"],"prefix":"10.1111","volume":"69","author":[{"given":"M. J.","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Gartnavel General Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Gartnavel General Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rowell","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Halliday","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Gartnavel General Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Lumsden","sequence":"additional","affiliation":[{"name":"Reproductive and Maternal Medicine Glasgow Royal Infirmary Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Golden Jubilee National Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Binning","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Gartnavel General Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"McConnachie","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,24]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Hip Fracture: the Management of Hip Fracture in Adults","author":"National Institute for Health and Clinical Care Excellence","year":"2011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2011.06957.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38790.468519.55"},{"key":"e_1_2_7_5_1","first-page":"CD001159","article-title":"Nerve blocks (subcostal, lateral cutaneous, femoral, triple, psoas) for hip fractures","volume":"1","author":"Parker MJ","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_6_1","unstructured":"The Medicines for Human Use (Clinical Trial) Regulations 2004 (SI 2004\/1031) as amended (SI 2006\/1928 SI 2006\/2984 SI 2008\/941 SI 2009\/1164 SI 2010\/1882). Number 1031 and Amendment 1928.1\u20104\u20102004."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1965.10480843"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1953.10483472"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.2012.687494"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12683","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:19:07Z","timestamp":1761668347000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,24]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/anae.12683"],"URL":"https:\/\/doi.org\/10.1111\/anae.12683","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,24]]}}}