{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:53:46Z","timestamp":1791255226864,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Sugammadex is a drug used to reverse neuromuscular blockade induced by rocuronium or vecuronium. It has not yet been approved by the Food and Drug Administration in the USA due to concerns regarding hypersensitivity. The objective of this review was to identify similarities in the presentation of hypersensitivity reactions to sugammadex. A comprehensive search was performed in PubMed, Scopus and Web of Science for cases reporting hypersensitivity reactions to sugammadex. In addition, we contacted regulatory agencies and the company marketing the drug for unpublished reports. Reports were included if they were in English, primary investigations, lacked an alternative probable explanation for the reaction and included a comprehensive description of the hypersensitivity. We identified 15 cases of hypersensitivity following sugammadex administration. All cases that reported exact timing (14\/15) occurred in 4\u00a0min or less. Most of the patients (11\/15; 73%) met World Anaphylaxis Organization criteria for anaphylaxis. Awareness must be raised for the possibility of drug\u2010induced hypersensitivity during the critical 5\u2010min period immediately following sugammadex administration.<\/jats:p>","DOI":"10.1111\/anae.12736","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T05:42:52Z","timestamp":1400737372000},"page":"1251-1257","source":"Crossref","is-referenced-by-count":105,"title":["Hypersensitivity associated with sugammadex administration: a systematic review"],"prefix":"10.1111","volume":"69","author":[{"given":"A.","family":"Tsur","sequence":"first","affiliation":[{"name":"Soroka University Medical Center Ben\u2010Gurion University of the Negev Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kalansky","sequence":"additional","affiliation":[{"name":"Medical School for International Health Ben\u2010Gurion University of the Negev Faculty of Health Sciences in Collaboration with Columbia University Medical Center Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05868.x"},{"key":"e_1_2_6_3_1","first-page":"57","article-title":"Sugammadex as a reversal agent for neuromuscular block: an evidence\u2010based review","volume":"8","author":"Schaller SJ","year":"2013","journal-title":"Core Evidence"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000244594.63318.fc"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969070-00008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/389782"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05870.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537210-000000000-00000"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32832c605b"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.65.6.495"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.65.6.501"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318211496c"},{"key":"e_1_2_6_15_1","first-page":"746","article-title":"Case of anaphylactic reaction caused by sugammadex","volume":"61","author":"Motoyama Y","year":"2012","journal-title":"Masui"},{"key":"e_1_2_6_16_1","first-page":"1261","article-title":"Two cases of anaphylactoid reaction after administration of sugammadex","volume":"61","author":"Ohshita N","year":"2012","journal-title":"Masui"},{"issue":"1","key":"e_1_2_6_17_1","first-page":"1145","article-title":"Be careful about anaphylactic shock by antagonism of the neuromuscular blockade~ cases of anaphylactic shock induced by sugammadex","volume":"40","author":"Takahiro T","year":"2012","journal-title":"Critical Care Medicine"},{"key":"e_1_2_6_18_1","first-page":"71","article-title":"Three cases of suspected anaphylactic shock due to sugammadex","volume":"20","author":"Takazawa T","year":"2013","journal-title":"Journal of the Japanese Society of Intensive Care Medicine"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.64.1.3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2011.08.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1404200102"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2011.09.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes137"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1404200116"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06611.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2012.08.010"},{"key":"e_1_2_6_27_1","first-page":"382","article-title":"Severe reaction following sugammadex injection: hypersensitivity?","volume":"22","author":"Soria A","year":"2012","journal-title":"Journal of Investigative Allergology and Clinical Immunology"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-013-9931-9"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1404200115"},{"key":"e_1_2_6_30_1","first-page":"199","article-title":"A case report of anaphylaxis associated with sugammadex administration in a pediatric oral surgical case","volume":"41","author":"Mimaru K","year":"2013","journal-title":"Journal of Japanese Dental Society of Anesthesiology"},{"issue":"2","key":"e_1_2_6_31_1","first-page":"S78","article-title":"Allied health: anaphylaxis after anesthetic reversal","volume":"5","author":"Chugo S","year":"2012","journal-title":"World Allergy Organization Journal"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/BF03256915","article-title":"Safety, tolerability and pharmacokinetics of sugammadex using single high doses (up to 96\u00a0mg\/kg) in healthy adult subjects: a randomized, double\u2010blind, crossover, placebo\u2010controlled, single\u2010centre study","volume":"30","author":"Peeters PA","year":"2010","journal-title":"Clinical Drug Investigation"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2004.05.008"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12736","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:47:40Z","timestamp":1761688060000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/anae.12736"],"URL":"https:\/\/doi.org\/10.1111\/anae.12736","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}