{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:30:14Z","timestamp":1791239414572,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Margaret River Friends of the Telethon Institute"},{"DOI":"10.13039\/100010289","name":"Princess Margaret Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010289","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Woolworths Australia via Princess Margaret Hospital Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Summary<\/jats:title>\n \n Three quarters of all critical incidents and a third of all peri\u2010operative cardiac arrests in paediatric anaesthesia are caused by adverse respiratory events. We screened for risk factors from children's and their families' histories, and assessed the usefulness of common markers of allergic sensitisation of the airway as surrogates for airway inflammation and increased risk for adverse respiratory events. One hundred children aged up to 16\u00a0years with two or more risk factors undergoing elective surgery were included in the study. Eosinophil counts, IgE level, specific IgE for\n D. pteronyssinus<\/jats:italic>\n , cat epithelia and Gx2 (grass pollen) were measured for each child and adverse respiratory events (bronchospasm, laryngospasm, oxygen desaturation <\u00a095%, severe persistent coughing, airway obstruction and postoperative stridor) were recorded. Twenty\u2010one patients had an adverse respiratory event but allergic markers were poor predictors. Binary logistic regression showed a lack of predictive value of the eosinophil range and adverse respiratory events (p\u00a0=\u00a00.249).\n Receiver operating characteristic (ROC)<\/jats:styled-content>\n curves for the presence of adverse respiratory events vs level of specific IgE antibody (to Gx2 (\n AUC<\/jats:styled-content>\n 0.614), cat epithelia (0.564) and\n D. pteronyssinus<\/jats:italic>\n (0.520)) demonstrated poor predictive values. However, the presence of risk factors was strongly associated with adverse respiratory events (p\u00a0<\u00a00.001) and a\n ROC<\/jats:styled-content>\n \u2010curve analysis indicated a fair capacity to predict adverse respiratory events (\n AUC<\/jats:styled-content>\n 0.788). There was a significant difference (p\u00a0=\u00a00.001) between the presence of adverse respiratory events in patients with more than four (p\u00a0=\u00a00.006), compared with less than four (p\u00a0=\u00a00.001), risk factors. We conclude that while risk factors taken from the child's (or family) history proved good predictors of adverse respiratory events, immunological markers of allergic sensitisation demonstrated low predictive values. Pre\u2010operative identification of children at high risk for an adverse respiratory event should rely on clinical, rather than immunological, assessment.\n <\/jats:p>","DOI":"10.1111\/anae.12946","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T04:21:51Z","timestamp":1416889311000},"page":"440-444","source":"Crossref","is-referenced-by-count":34,"title":["Peri\u2010operative adverse respiratory events in children"],"prefix":"10.1111","volume":"70","author":[{"given":"B. S.","family":"von Ungern\u2010Sternberg","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacology The University of Western Australia Perth Western Australia Australia"},{"name":"Department of Anaesthesia and Pain Management Princess Margaret Hospital for Children Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ramgolam","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"},{"name":"Department of Anaesthesia and Pain Management Princess Margaret Hospital for Children Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Hall","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Sly","sequence":"additional","affiliation":[{"name":"Queensland Children's Medical Research Institute The University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Habre","sequence":"additional","affiliation":[{"name":"Paediatric Anaesthesia Unit Geneva Children's Hospital University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00767.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61193-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.2.167"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-160"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110103251504"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2006.04859.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092163"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00022908"},{"key":"e_1_2_7_10_1","first-page":"357","article-title":"The role of eosinophils in allergic airway inflammation","volume":"9","author":"Walsh ER","year":"2010","journal-title":"Discovery Medicine"},{"key":"e_1_2_7_11_1","first-page":"532","article-title":"Bronchial hyperresponsiveness and airway inflammation in patients with seasonal allergic rhinitis","volume":"21","author":"Skiepko R","year":"2011","journal-title":"Journal of Investigational Allergology and Clinical Immunology"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.00967.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02097.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02098.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30252-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/74.3.250"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.12946","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.12946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:12:53Z","timestamp":1761693173000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.12946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/anae.12946"],"URL":"https:\/\/doi.org\/10.1111\/anae.12946","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,25]]}}}