{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:23:24Z","timestamp":1789712604906,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SingHealth Foundation Grant","award":["SHF\/CTG047\/2012"],"award-info":[{"award-number":["SHF\/CTG047\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hypotension occurs commonly during spinal anaesthesia for caesarean section, associated with maternal and fetal adverse effects. We developed a double\u2010vasopressor automated system with a two\u2010step algorithm and continuous non\u2010invasive haemodynamic monitoring using the Nexfin\n                    <jats:sup>\u2122<\/jats:sup>\n                    device. The system delivered 25\u00a0\u03bcg phenylephrine every 30\u00a0s when systolic blood pressure was between 90% and 100% of baseline, or 2\u00a0mg ephedrine at this blood pressure range and heart rate &lt;\u00a060 beats.min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; and 50\u00a0\u03bcg phenylephrine or 4\u00a0mg ephedrine when systolic blood pressure was &lt;\u00a090% of baseline with the same heart rate criterion. Fifty\u2010seven women received standardised spinal anaesthesia. Twenty\u2010seven (47.4%) had at least one reading of hypotension defined as systolic blood pressure &lt;\u00a080% baseline. Systolic blood pressure was within 20% of the baseline in a mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) of 79.8 (20.9)% of measurements. Fifty\u2010three (93.0%) women required phenylephrine before delivery while 10 (17.5%) required ephedrine. Six women (10.5%) experienced nausea and three (5.3%) vomited. The system was able to achieve a low incidence of maternal hypotension with good maternal and fetal outcomes.\n                  <\/jats:p>","DOI":"10.1111\/anae.13008","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T06:08:23Z","timestamp":1422425303000},"page":"691-698","source":"Crossref","is-referenced-by-count":31,"title":["Assessment of an updated double\u2010vasopressor automated system using Nexfin\n                    <sup>\u2122<\/sup>\n                    for the maintenance of haemodynamic stability to improve peri\u2010operative outcome during spinal anaesthesia for caesarean section"],"prefix":"10.1111","volume":"70","author":[{"given":"B. L.","family":"Sng","sequence":"first","affiliation":[{"name":"Department of Women's Anaesthesia KK Women's and Children's Hospital Singapore"},{"name":"Centre for Quantitative Medicine Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Quantitative Medicine Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. N.","family":"Assam","sequence":"additional","affiliation":[{"name":"Centre for Quantitative Medicine Duke\u2010NUS Graduate Medical School Singapore"},{"name":"Singapore Clinical Research Institute Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Sia","sequence":"additional","affiliation":[{"name":"Department of Women's Anaesthesia KK Women's and Children's Hospital Singapore"},{"name":"Duke\u2010NUS Graduate Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3282ff5e41"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000192816.22989.ba"},{"key":"e_1_2_7_4_1","first-page":"CD002251","article-title":"Techniques for preventing hypotension during spinal anaesthesia for caesarean section","volume":"4","author":"Cyna AM","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328337ffc6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12000"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12460"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31824f94ed"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2011.07018.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01143186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05257.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200510000-00012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes339"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02646.x"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.13008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.13008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:12:40Z","timestamp":1761700360000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.13008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/anae.13008"],"URL":"https:\/\/doi.org\/10.1111\/anae.13008","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}