{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:51:40Z","timestamp":1782143500419,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T00:00:00Z","timestamp":1429315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Visiting Scholar Fund University of Cape Town, South Africa"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Haemodynamic and cardiac structural changes in severe pre\u2010eclampsia and in pregnant women with human immunodeficiency virus (\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    ) infection have not been clearly established. We performed transthoracic echocardiography on 105 women. Women with pre\u2010eclampsia demonstrated (mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ), untreated vs treated) preserved fractional shortening (40 (7.1)% vs 41 (8.6)%), a non\u2010dilated left ventricle (4.5 (0.49) cm vs 4.4 (0.44)\u00a0cm), increased mitral valve E\/septal e\u2032 (10.5 (3.3) vs 10.6 (2.8)), and preserved tricuspid annular plane systolic exertion (2.6 (0.36) cm vs 2.4 (0.51)\u00a0cm). Women with\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    infection demonstrated (mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ), HIV\u2010positive vs healthy) a reduced cardiac index (2.8 (0.64) ml.min\n                    <jats:sup>\u22121<\/jats:sup>\n                    .m\n                    <jats:sup>\u22122<\/jats:sup>\n                    vs 3.1 (0.7)\u00a0ml.min\n                    <jats:sup>\u22121<\/jats:sup>\n                    .m\n                    <jats:sup>\u22122<\/jats:sup>\n                    , p\u00a0=\u00a00.029), reduced septal s\u2032 tissue Doppler velocity (8.5 (1.5) cm.s\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs 9.3 (1.7)\u00a0cm.s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p\u00a0=\u00a00.042), increased left ventricular end\u2010diastolic area (7.6 (2.1) cm\n                    <jats:sup>2<\/jats:sup>\n                    vs 6.3 (1.7)\u00a0cm\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>,<\/jats:sub>\n                    p\u00a0=\u00a00.004), and reduced right ventricular s\u2032 and e\u2032 velocity (s\u2032 velocity 14.7 (3.1) cm.s\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs 7.0 (2.9)\u00a0cm.s\n                    <jats:sup>\u22121<\/jats:sup>\n                    p\u00a0=\u00a00.001, e\u2032\u00a0velocity 16.3 (4.1) cm.s\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs 18.7 (3.4)\u00a0cm.s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p\u00a0=\u00a00.013). The mitral value E\/septal e\u2032 was &gt;\u00a08 in 39% of patients with\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    . Fractional shortening (&lt;\u00a028%) was reduced in 10% of healthy women, and mitral valve E\/septal e\u2032 ratios were &gt;\u00a08 in 38% of that group. Women with pre\u2010eclampsia demonstrated preserved systolic function, with diastolic dysfunction. Women with\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    demonstrated reduced left and right ventricular systolic function, with increased ventricular dilatation.\n                  <\/jats:p>","DOI":"10.1111\/anae.13038","type":"journal-article","created":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T04:12:53Z","timestamp":1429330373000},"page":"1028-1038","source":"Crossref","is-referenced-by-count":13,"title":["Transthoracic echocardiographic assessment of haemodynamics in severe pre\u2010eclampsia and\n                    <scp>HIV<\/scp>\n                    in South Africa"],"prefix":"10.1111","volume":"70","author":[{"given":"A. T.","family":"Dennis","sequence":"first","affiliation":[{"name":"Department of Anaesthesia The Royal Women's Hospital Parkville Parkville Victoria Australia"},{"name":"Department of Pharmacology and Department of Obstetrics and Gynaecology The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Dyer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University of Cape Town and Groote Schuur Hospital Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University of Cape Town and Groote Schuur Hospital Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University of Cape Town and Groote Schuur Hospital Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Vincent's Hospital Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Swanevelder","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University of Cape Town and Groote Schuur Hospital Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01003.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1003462"},{"key":"e_1_2_8_4_1","unstructured":"Organization WH.Global update on the health sector response to HIV 2014.http:\/\/apps.who.int\/iris\/bitstream\/10665\/128494\/1\/9789241507585_eng.pdf?ua=1(accessed 19\/12\/2014)."},{"key":"e_1_2_8_5_1","unstructured":"Department of Health (South Africa) Saving Mothers 2008\u20132010: Fifth report on the confidential enquiries into maternal deaths in South Africa 2012.http:\/\/www.hst.org.za\/publications\/saving-mothers-2008-2010-fifth-report-confidential-enquiries-maternal-deaths-south-afri(accessed 13\/01\/2014)."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07193.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200404050-00004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2010.11.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162321"},{"key":"e_1_2_8_10_1","volume-title":"Maternal Deaths in Australia 2006\u20132010, Maternal Deaths series no.4, Cat. no. 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