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Five piglets were studied, whose median and lingual nerves were unilaterally injected post mortem with preset volumes of local anaesthetic, excised and subsequently made transparent with benzyl alcohol benzyl benzoate. Images were captured in three dimensions. The same contralateral nerves were used as controls. Using optical projection tomography, we observed differences between the internal organisation of the median and the lingual nerves, which potentially explain the variations in their susceptibility to injury. This was demonstrated in three dimensions as a disruption to the fascicles in the lingual nerve, and their displacement in the median nerve. This new technology offers potential for studying nerve microarchitecture topography and its tolerance to injection injury.<\/jats:p>","DOI":"10.1111\/anae.13066","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T22:05:08Z","timestamp":1427839508000},"page":"939-947","source":"Crossref","is-referenced-by-count":11,"title":["The utility of three\u2010dimensional optical projection tomography in nerve injection injury imaging"],"prefix":"10.1111","volume":"70","author":[{"given":"E.","family":"Cvetko","sequence":"first","affiliation":[{"name":"Institute of Anatomy Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"\u010capek","sequence":"additional","affiliation":[{"name":"Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Damjanovska","sequence":"additional","affiliation":[{"name":"Clinical Department of Anaesthesiology and Intensive Therapy University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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