{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:58Z","timestamp":1787013838019,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CARO Club Anesth\u00e9sie Reanimation en Obst\u00e9trique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Epidural blood patch is the gold standard treatment for post\u2010dural puncture headache, although hydroxyethyl starch may be a useful alternative to blood if the latter is contraindicated. The aim of this experimental study was to assess whether hydroxyethyl starch given via an indwelling intrathecal catheter resulted in clinical or histopathological changes suggestive of neurotoxicity. The study was conducted in rats that were randomly allocated to receive three 10\u2010\u03bcl injections on consecutive days of either saline or hydroxyethyl starch administered via the intrathecal catheter. Eight rats were given injections of saline 0.9% and 11 were given 6% hydroxyethyl starch 130\/0.4 derived from thin\u00a0boiling waxy corn starch in 0.9% sodium chloride (Voluven\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ). Daily clinical evaluation, activity measured by actimetry and neuropathological analysis of the spinal cord were subsequently performed to assess for signs of neurotoxicity. No clinical or actimetric changes were observed in either group following intrathecal saline or hydroxyethyl starch administration. Histopathological examination showed non\u2010specific changes with no differences between the two groups. This experimental study in the rat suggests that repeated intrathecal injection of hydroxyethyl starch is not associated with neurotoxicity.\n                  <\/jats:p>","DOI":"10.1111\/anae.13076","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T07:54:56Z","timestamp":1429775696000},"page":"1045-1051","source":"Crossref","is-referenced-by-count":9,"title":["Neurotoxicity of intrathecal 6% hydroxyethyl starch 130\/0.4 injection in a rat model"],"prefix":"10.1111","volume":"70","author":[{"given":"O.","family":"Vassal","sequence":"first","affiliation":[{"name":"Department of Paediatric Anaesthesia H\u00f4pital Femme M\u00e8re Enfant Centre Hospitalier Universitaire Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Del Carmine","sequence":"additional","affiliation":[{"name":"Aniphy Claude Bernard University University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010A.","family":"Beuriat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery H\u00f4pital Pierre Wertheimer Centre Hospitalier Universitaire Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010P.","family":"Desgranges","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia H\u00f4pital Femme M\u00e8re Enfant Centre Hospitalier Universitaire Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gadot","sequence":"additional","affiliation":[{"name":"Department of Histology ANIPath Laennec University University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Allaouchiche","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia H\u00f4pital Femme M\u00e8re Enfant Centre Hospitalier Universitaire Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Timour\u2010Chah","sequence":"additional","affiliation":[{"name":"Aniphy Claude Bernard University University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chassard","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia H\u00f4pital Femme M\u00e8re Enfant Centre Hospitalier Universitaire Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199506000-00019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6882.874"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021057"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05285.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03016283"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg231"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3282f8e21a"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.36076\/ppj.2009\/12\/639","article-title":"Allogeneic epidural blood patch in the setting of persistent spinal headache and disseminated coccidioidomycosis","volume":"12","author":"Trentman TL","year":"2009","journal-title":"Pain Physician"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199901000-00031"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2013.01.003"},{"issue":"2","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/026119290203002S36","article-title":"Directive 86\/609\/EEC on the protection of animals used for experimental and other scientific purposes","volume":"30","author":"Louhimies S","year":"2002","journal-title":"Alternatives to Laboratory Animals"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(76)90029-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8179"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199911000-00071"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019377"},{"key":"e_1_2_7_17_1","first-page":"175","article-title":"A simple, safe and effective approach to prevent postdural puncture headache: epidural saline injection","volume":"41","author":"Kiki I","year":"2009","journal-title":"Eurasian Journal of Medicine"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.36076\/ppj.2011\/14\/271","article-title":"Caudal normal saline injections for the treatment of post\u2010dural puncture headache","volume":"14","author":"Abdulla S","year":"2011","journal-title":"Pain Physician"},{"key":"e_1_2_7_19_1","first-page":"227","article-title":"Management of postdural puncture headache by epidural saline delivered with a patient\u2010controlled pump \u2013 a case report","volume":"44","author":"Liu S","year":"2006","journal-title":"Acta Anaesthesiologica Taiwanica"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197803000-00012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005400170027"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(93)90086-T"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199908000-00039"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12151"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.183-az0320.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021506001037"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1994.hed3405265.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021850"},{"key":"e_1_2_7_29_1","first-page":"78","article-title":"Relief of post\u2010lumbar puncture headache with epidural Dextran 40: a preliminary report","volume":"14","author":"Barrios\u2010Alarcon J","year":"1989","journal-title":"Regional Anesthesia"},{"key":"e_1_2_7_30_1","first-page":"357","article-title":"Prevention of post dural puncture headache with epidural\u2010administered dextran 40","volume":"17","author":"Salvador L","year":"1992","journal-title":"Regional Anesthesia"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4472.99310"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200310000-00032"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200208000-00021"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2008.00251.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1639"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.13076","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.13076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:00:21Z","timestamp":1761699621000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.13076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/anae.13076"],"URL":"https:\/\/doi.org\/10.1111\/anae.13076","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]}}}