{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:07:07Z","timestamp":1783573627707,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Intranasal dexmedetomidine has been used successfully for sedation in children. A mucosal atomisation device delivers an atomised solution to the nasal mucosa which facilitates rapid and effective delivery of medication to the systemic circulation. We compared intranasal delivery of dexmedetomidine in a dose of 3 \u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    by either atomiser or drops from a syringe in children &lt; 3 years old undergoing transthoracic echocardiography. Two hundred and seventy\u2010nine children were randomly assigned to one or other group. One hundred and thirty\u2010seven children received dexmedetomidine by atomiser and 142 by drops. The successful sedation rate was 82.5% (95% CI 75.3\u201387.9%) and 84.5% (95% CI 77.7\u201389.5%) for atomiser and drops, respectively (p = 0.569). Sedation tended to be less successful in older children (p = 0.028, OR 0.949, 95% CI 0.916\u20130.983). There were no significant complications. We conclude that both modes of dexmedetomidine administration are equally effective, although increasing age of the child was associated with a decreased likelihood of successful sedation.\n                  <\/jats:p>","DOI":"10.1111\/anae.13407","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T08:19:59Z","timestamp":1456993199000},"page":"522-528","source":"Crossref","is-referenced-by-count":72,"title":["A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops"],"prefix":"10.1111","volume":"71","author":[{"given":"B. L.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. X.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. Q.","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. R.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University of Hong Kong Shenzhen Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200003000-00035"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07309.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06453.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31816c8929"},{"key":"e_1_2_7_7_1","first-page":"859","article-title":"The effectiveness and safety of intranasal dexmedetomidine and oral chloral hydrate for pediatric CT sedation","volume":"29","author":"Li BL","year":"2013","journal-title":"Journal of Clinical Anesthesiology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12533"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12687"},{"key":"e_1_2_7_10_1","first-page":"401","article-title":"Comparison of drops versus spray administration of intranasal midazolam in two\u2010 and three\u2010year\u2010old children for dental sedation","volume":"27","author":"Primosch RE","year":"2005","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.36.1.1774746504g28656"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0755-7.00062-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182495e1b"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0616"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01186.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03207.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01944.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1002-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02468.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200409000-00028"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0417-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70256-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1445"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.13407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.13407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:31:32Z","timestamp":1761690692000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.13407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,3]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/anae.13407"],"URL":"https:\/\/doi.org\/10.1111\/anae.13407","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,3]]}}}