{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:16:40Z","timestamp":1761844600311,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["26462371","25234567"],"award-info":[{"award-number":["26462371","25234567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We performed a randomised controlled double\u2010blinded study of patients having laparoscopic colectomy with bilateral transversus abdominis plane block plus rectus sheath block, comparing a control group receiving 80 ml levobupivacaine 0.2% in saline with a dextran group receiving 80 ml levobupivacaine 0.2% in 8% low\u2010molecular weight dextran. Twenty\u2010seven patients were studied in each group. The mean (SD) maximum plasma concentration of levobupivacaine in the control group (1410 (322) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was higher than the dextran group (1141 (287) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; p = 0.004), and was reached more quickly (50.6 (30.2) min vs 73.2 (24.6) min; p = 0.006). The area under the plasma concentration\u2013time curve from 0 min to 240 min in the control group (229,124 (87,254) ng.min.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was larger than in the dextran group (172,484 (50,502) ng.min.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; p = 0.007). The median (IQR [range]) of the summated numerical pain rating score at rest during the first postoperative 24 h in the control group (16 (9\u201320 [3\u201331]) was higher than in the dextran group (8 (2\u201311 [0\u201318]); p = 0.0001). In this study, adding dextran to levobupivacaine decreased the risk of levobupivacaine toxicity while providing better analgesia.\n                  <\/jats:p>","DOI":"10.1111\/anae.13408","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T07:55:04Z","timestamp":1456473304000},"page":"411-416","source":"Crossref","is-referenced-by-count":25,"title":["Levobupivacaine \u2013 dextran mixture for transversus abdominis plane block and rectus sheath block in patients undergoing laparoscopic colectomy: a randomised controlled trial"],"prefix":"10.1111","volume":"71","author":[{"given":"T.","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Osaka City University Medical School Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka City University Medical School Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Operating Theatre Osaka Rosai Hospital Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia First Towakai Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Muguruma","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Osaka City University Medical School Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Osaka City University Medical School Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Kochi Medical School Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka City University Medical School Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06203.x"},{"key":"e_1_2_6_3_1","first-page":"1241","article-title":"Transversus abdominis plane block in combination with general anesthesia provides better intraoperative hemodynamic control and quicker recovery than general anesthesia alone in high\u2010risk abdominal surgery patients","volume":"78","author":"Tsuchiya M","year":"2012","journal-title":"Minerva 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