{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:00:04Z","timestamp":1793592004162,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We re\u2010analysed prospective data collected by anaesthetists in the Anaesthesia Sprint Audit of Practice (\n                    <jats:styled-content style=\"fixed-case\">ASAP<\/jats:styled-content>\n                    \u20101) to describe associations with linked outcome data. Mortality was 165\/11,085 (1.5%) 5 days and 563\/11,085 (5.1%) 30 days after surgery and was not associated with anaesthetic technique (general vs. spinal, with or without peripheral nerve blockade). The risk of death increased as blood pressure fell: the odds ratio (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) for mortality within five days after surgery was 0.983 (0.973\u20130.994) for each 5 mmHg intra\u2010operative increment in systolic blood pressure, p = 0.0016, and 0.980 (0.967\u20130.993) for each mmHg increment in mean pressure, p = 0.0039. The equivalent odds ratios (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) for 30\u2010day mortality were 0.968 (0.951\u20130.985), p = 0.0003 and 0.976 (0.964\u20130.988), p = 0.0001, respectively. The lowest systolic blood pressure after intrathecal local anaesthetic relative to before induction was weakly correlated with a higher volume of subarachnoid bupivacaine: r\n                    <jats:sup>2<\/jats:sup>\n                    \u22120.10 and \u22120.16 for hyperbaric and isobaric bupivacaine, respectively. A mean 20% relative fall in systolic blood pressure correlated with an administered volume of 1.44 ml hyperbaric bupivacaine. Future research should focus on refining standardised anaesthesia towards administering lower doses of spinal (and general) anaesthesia and maintaining normotension.\n                  <\/jats:p>","DOI":"10.1111\/anae.13415","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T11:57:55Z","timestamp":1457179075000},"page":"506-514","source":"Crossref","is-referenced-by-count":149,"title":["Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective\n                    <scp>UK<\/scp>\n                    Anaesthesia Sprint Audit of Practice (\n                    <scp>ASAP<\/scp>\n                    \u20102)"],"prefix":"10.1111","volume":"71","author":[{"given":"S. M.","family":"White","sequence":"first","affiliation":[{"name":"Brighton and Sussex University Hospitals NHS Trust Brighton East Sussex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. K.","family":"Moppett","sequence":"additional","affiliation":[{"name":"Anaesthesia and Critical Care Section Division of Clinical Neuroscience University of Nottingham Queen's Medical Centre Campus Nottingham University Hospitals NHS Trust Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Peterborough and Stamford Hospitals NHS Trust Peterborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Hip Fracture Database, Falls and Fragility Fracture Audit Programme Clinical Effectiveness and Evaluation Unit Royal College of Physicians London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wakeman","sequence":"additional","affiliation":[{"name":"National Hip Fracture Database, Falls and Fragility Fracture Audit Programme Clinical Effectiveness and Evaluation Unit Royal College of Physicians London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Boulton","sequence":"additional","affiliation":[{"name":"National Hip Fracture Database, Falls and Fragility Fracture Audit Programme Clinical Effectiveness and Evaluation Unit Royal College of Physicians London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Plant","sequence":"additional","affiliation":[{"name":"The Royal National Orthopaedic Hospital Stanmore Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Gloucestershire Royal Hospital Gloucester Gloucestershire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pappenheim","sequence":"additional","affiliation":[{"name":"Association of Anaesthetists of Great Britain and Ireland London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Majeed","sequence":"additional","affiliation":[{"name":"King Fahad Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. T.","family":"Currie","sequence":"additional","affiliation":[{"name":"National Hip Fracture Database London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P. W.","family":"Grocott","sequence":"additional","affiliation":[{"name":"Anaesthesia and Critical Care Medicine University of Southampton and Southampton NIHR Respiratory Biomedical Research Unit Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07120.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182545e7c"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.6499"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4022"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.02.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12542"},{"key":"e_1_2_6_8_1","volume-title":"National Hip Fracture Database extended report 2014","author":"Royal College of 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