{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:21:24Z","timestamp":1776450084348,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Summary<\/jats:title>\n \n Recent studies have shown that nasal oxygen delivery can prolong the time to desaturation during apnoea in the non\u2010pregnant population. We investigated the benefits of apnoeic oxygenation during rapid sequence induction in the obstetric population using computational modelling. We used the Nottingham Physiology Simulator, and pre\u2010oxygenated seven models of pregnancy for 3\u00a0min using F\n i<\/jats:sub>\n O\n 2<\/jats:sub>\n 1.0, before inducing apnoea. We found that increasing F\n i<\/jats:sub>\n O\n 2<\/jats:sub>\n at the open glottis increased the time to desaturation, extending the time taken for S\n a<\/jats:sub>\n O\n 2<\/jats:sub>\n to reach 40% from 4.5\u00a0min to 58\u00a0min in the average parturient model (not in labour). Our study suggests that a small increase in time to desaturation could be achieved at F\n i<\/jats:sub>\n O\n 2<\/jats:sub>\n 0.4\u20130.6, which could be delivered by standard nasal cannulae. The greatest increases in time to desaturation were seen at F\n i<\/jats:sub>\n O\n 2<\/jats:sub>\n 1.0, which could be delivered by high\u2010flow nasal cannulae under ideal conditions.\n <\/jats:p>","DOI":"10.1111\/anae.13563","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:52:42Z","timestamp":1469062362000},"page":"1077-1080","source":"Crossref","is-referenced-by-count":29,"title":["Apnoeic oxygenation in pregnancy: a modelling investigation"],"prefix":"10.1111","volume":"71","author":[{"given":"A.","family":"Pillai","sequence":"first","affiliation":[{"name":"Academic Anaesthesia and Critical Care Division of Clinical Neuroscience University of Nottingham Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chikhani","sequence":"additional","affiliation":[{"name":"Academic Anaesthesia and Critical Care Division of Clinical Neuroscience University of Nottingham Nottingham UK"},{"name":"Nottingham University Hospitals NHS Trust Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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