{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:06:59Z","timestamp":1790950019223,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R178\/1110"],"award-info":[{"award-number":["R178\/1110"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Concerns have been raised about the effects on cognition of anaesthesia for surgery, especially in elderly people. We recorded cognitive decline in a cohort of 394 people (198 women) with median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    ) age at recruitment of 72.6 (66.6\u201377.8) years, of whom 109 had moderate or major surgery during a median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    ) follow\u2010up of 4.1 (2.0\u20137.6) years. Cognitive decline was more rapid in people who on recruitment were: older, p = 0.0003; male, p = 0.027; had worse cognition, p &lt; 0.0001; or carried the \u03b54 allele of apoliprotein E (\n                    <jats:italic>APOE\u03b54<\/jats:italic>\n                    ), p = 0.008; and after an operation if cognitive impairment was already diagnosed, p = 0.0001. Cognitive decline appears to accelerate after surgery in elderly patients diagnosed with cognitive impairment, but not other elderly patients.\n                  <\/jats:p>","DOI":"10.1111\/anae.13571","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T16:13:59Z","timestamp":1470672839000},"page":"1144-1152","source":"Crossref","is-referenced-by-count":69,"title":["Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort"],"prefix":"10.1111","volume":"71","author":[{"given":"D.","family":"Patel","sequence":"first","affiliation":[{"name":"Northwick Park Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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