{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:16:22Z","timestamp":1793693782012,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Post\u2010spinal hypotension remains a common and clinically\u2010important problem during caesarean section, and accurate pre\u2010operative prediction of this complication might enhance clinical management. We conducted a prospective, single\u2010centre, observational study of heart rate variability in 102 patients undergoing elective caesarean section in a South African regional hospital. We performed Holter recording for \u2265 5 min in the hour preceding spinal anaesthesia. The low\u2010frequency\/high\u2010frequency ratio component of heart rate variability was compared, using a logistic regression model, with baseline heart rate and body mass index (\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    ) as a predictor of hypotension (defined as systolic arterial pressure &lt; 90 mmHg) occurring from the time of spinal insertion until 15 min after delivery of the baby. We also assessed clinically relevant cut\u2010point estimations for low\u2010frequency\/high\u2010frequency ratio. Low\u2010frequency\/high\u2010frequency ratio predicted hypotension (p = 0.046;\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    1.478, 95%CI 1.008\u20101.014), with an optimal cut\u2010point estimation of 2.0; this threshold predicted hypotension better than previously determined thresholds (p = 0.003; c\u2010statistic 0.645). Baseline heart rate (p = 0.20;\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    1.022, 95%CI 0.988\u20101.057) and\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    (p = 0.60;\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    1.017, 95%CI 0.954\u20101.085) did not predict hypotension. Heart rate variability analysis is a potentially useful clinical tool for the prediction of hypotension. Future studies should consider a low\u2010frequency\/high\u2010frequency ratio threshold of 2.0 for prospective validation.\n                  <\/jats:p>","DOI":"10.1111\/anae.13813","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:47:39Z","timestamp":1485737259000},"page":"603-608","source":"Crossref","is-referenced-by-count":47,"title":["Heart rate variability as a predictor of hypotension following spinal for elective caesarean section: a prospective observational study"],"prefix":"10.1111","volume":"72","author":[{"given":"D. G.","family":"Bishop","sequence":"first","affiliation":[{"name":"Metropolitan Department of Anaesthetics, Critical Care and Pain Management University of KwaZulu\u2010Natal Pietermaritzburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cairns","sequence":"additional","affiliation":[{"name":"Metropolitan Department of Anaesthetics, Critical Care and Pain Management University of KwaZulu\u2010Natal Pietermaritzburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Grobbelaar","sequence":"additional","affiliation":[{"name":"Metropolitan Department of Anaesthetics, Critical Care and Pain Management University of KwaZulu\u2010Natal Pietermaritzburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N.","family":"Rodseth","sequence":"additional","affiliation":[{"name":"Metropolitan Department of Anaesthetics, Critical Care and Pain Management University of KwaZulu\u2010Natal Pietermaritzburg South Africa"},{"name":"Outcomes Research Consortium Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200006000-00024"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2005.04223.x"},{"key":"e_1_2_7_4_1","unstructured":"KwaZulu Natal Department of Health.Saving Mothers 2011\u20132013: Sixth report on the Confidential Enquiries into Maternal Deaths in South Africa 2014.www.kznhealth.gov.za\/mcwh\/Maternal\/Saving-Mothers-2011-2013-short-report.pdf(accessed 11\/12\/2016)."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000140953.40059.E6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200506000-00005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03020493"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12992"},{"key":"e_1_2_7_9_1","first-page":"21","article-title":"Correlation between the body mass index (BMI) of pregnant women and the development of hypotension after spinal anesthesia for cesarean section","volume":"61","author":"Nani FS","year":"2011","journal-title":"Revista Brasileira de Anestesiologia"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-009-9168-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010-w1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00103-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4509"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200604000-00005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.1.97"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000178181.91250.99"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199702000-00011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/22201181.2016.1202605"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.1826"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.2.482"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200603000-00022"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877\u2010016\u20109906\u20109"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000728"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02239.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328337ffc6"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.13813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.13813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:23:02Z","timestamp":1761690182000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.13813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,30]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/anae.13813"],"URL":"https:\/\/doi.org\/10.1111\/anae.13813","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,30]]}}}