{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T01:18:38Z","timestamp":1779326318407,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Psychiatry, Duke University Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Previous pilot work has established an association between obstructive sleep apnoea and the development of acute postoperative delirium , but it remains unclear to what extent this risk factor is modifiable in the \u2018real world\u2019 peri\u2010operative setting. In a single\u2010blind randomised controlled trial, 135 elderly surgical patients at risk for obstructive sleep apnoea were randomly assigned to receive peri\u2010operative continuous positive airway pressure (\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    ) or routine care. Of the 114 patients who completed the study, 21 (18.4%) experienced delirium. Delirium was equally common in both groups: 21% (12 of 58 subjects) in the CPAP group and 16% (9 of 56 subjects) in the routine care group (\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    = 1.36 [95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    0.52\u20133.54], p = 0.53). Delirious subjects were slightly older \u2013 mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) age 68.9 (10.7) vs. 64.9 (8.2), p = 0.07 \u2013 but had nearly identical pre\u2010operative\n                    <jats:styled-content style=\"fixed-case\">STOP<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">Bang<\/jats:styled-content>\n                    scores (4.19 (1.1) versus 4.27 (1.3), p = 0.79). Subjects in the CPAP group used their devices for a median (IQR [range]) of 3 (0.25\u20135 [0\u201312]) nights pre\u2010operatively (2.9 (0.1\u20134.8 [0.0\u201312.7]) hours per night) and 1 (0\u20132 [0\u20132]) nights postoperatively (1.4 (0.0\u20135.1 [0.0\u201311.6]) hours per night). Among the CPAP subjects, the residual pre\u2010operative apnoea\u2013hypopnea index had a significant effect on delirium severity (p = 0.0002). Although we confirm that apnoea is associated with postoperative delirium, we did not find that providing a short\u2010course of auto\u2010titrating CPAP affected its likelihood or severity. Voluntary adherence to CPAP is particularly poor during the initiation of therapy.\n                  <\/jats:p>","DOI":"10.1111\/anae.13833","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:33:07Z","timestamp":1488414787000},"page":"729-736","source":"Crossref","is-referenced-by-count":35,"title":["A randomised trial of peri\u2010operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty"],"prefix":"10.1111","volume":"72","author":[{"given":"J. W.","family":"Nadler","sequence":"first","affiliation":[{"name":"University of Rochester Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fang","sequence":"additional","affiliation":[{"name":"Singapore General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. A.","family":"Preud'Homme","sequence":"additional","affiliation":[{"name":"Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"Daughtry","sequence":"additional","affiliation":[{"name":"Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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D.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Duke University Durham North Carolina USA"},{"name":"Executive Vice Chair for the Langley Porter Psychiatric Institute (LPPI) University of California at San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31824b94fc"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62108-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0477-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2012.0319"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12638"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4892"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes308"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000051"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000407"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.08.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes465"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000053"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-013-0846-z"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318297d89a"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001160"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2012.08.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-012-8182-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0989"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes022"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143697"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.13.2.229"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-12-941"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07155.x"},{"key":"e_1_2_6_26_1","first-page":"148","article-title":"The use of auto\u2010titrating continuous positive airway pressure for treatment of adult obstructive sleep apnea. 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