{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:06:18Z","timestamp":1790406378312,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Optimal immunological homoeostasis determines the long\u2010term recovery of patients in the postoperative period. The functional adaptability of monocytes plays a pivotal role in adjusting the host's response to an insult, immunostasis and long\u2010term health, and may help to determine successful recovery. We undertook a longitudinal analysis of the functional adaptability of monocytes in 20 patients undergoing heart surgery with cardiopulmonary bypass, as a model of severe stress. Using each patient's pre\u2010cardiopulmonary bypass data as a baseline, we investigated the characteristics of peripheral blood monocytes\u2019 functional plasticity in\u2010vitro before elective bypass, and three\u00a0months afterwards. Approximately 30% of subjects showed diminished monocyte plasticity, as demonstrated by decreased monocyte differentiation into dendritic cells three\u00a0months after bypass. Diminished monocyte functional plasticity was related to over\u2010production of macrophage colony\u2010stimulating factor. Adding a neutralising antibody to macrophage colony\u2010stimulating factor corrected the monocytes\u2019 differentiation defect. Finally, patients with reduced monocyte plasticity had significantly elevated serum C\u2010reactive protein, with a concomitant increase in cytomegalovirus IgG antibody titres, suggestive of the acquisition of immuno\u2010suppressive traits. Our study shows that severe surgical stress resulted in a lasting immunological defect in individuals who had seemingly recovered.<\/jats:p>","DOI":"10.1111\/anae.13868","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T14:15:32Z","timestamp":1492092932000},"page":"879-888","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term alterations in monocyte function after elective cardiac surgery"],"prefix":"10.1111","volume":"72","author":[{"given":"M.","family":"Zawadka","sequence":"first","affiliation":[{"name":"2nd Department of Anaesthesiology and Intensive Care Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wahome","sequence":"additional","affiliation":[{"name":"Undergraduate Student Department Lincoln University Lincoln Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Oszkiel","sequence":"additional","affiliation":[{"name":"Department of Epigenetics Mossakowski Medical Research Centre, PAS. 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