{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:53:46Z","timestamp":1787496826038,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We wished to evaluate whether inhibition of the systemic inflammatory response by a single pre\u2010operative dose of methylprednisolone reduced markers of early endothelial damage after fast\u2010track total knee arthroplasty. We randomly allocated 70 patients undergoing elective unilateral total knee arthroplasty (1:1) to receive either pre\u2010operative intravenous methylprednisolone 125 mg (methylprednisolone group) or isotonic saline (control group). All procedures were performed under spinal anaesthesia without a tourniquet, using a standardised multimodal analgesic regime. The outcomes included changes in Syndecan\u20101 concentrations, a marker of glycocalyx degradation, markers of endothelial cell damage and activation (plasma soluble thrombomodulin and\n                    <jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>\n                    \u2010Selectin), and permeability by vascular endothelial growth factor, as well as C\u2010reactive protein concentrations. Blood samples were collected at baseline and 2 h, 6 h and 24 h after surgery, with complete sampling from 63 patients for analyses. Methylprednisolone significantly reduced markers of endothelial damage at 24 h following surgery compared with saline (methylprednisolone group vs. control group, adjusted means (\n                    <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\n                    )) expressed by circulating Syndecan\u20101: 11.6 (1.0) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 13.4 (1.1) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    p = 0.046; soluble thrombomodulin: 5.1 (0.1) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 5.7 (0.2) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p = 0.009;\n                    <jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>\n                    \u2010Selectin: 64.8 (1.8) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 75.7 (1.9) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p = 0.001, and vascular endothelial growth factor: 35.3 (2.7) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 58.5 (2.8) ng.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p &lt; 0.001. The effect of the intervention increased with time for soluble thrombomodulin,\n                    <jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>\n                    \u2010Selectin and vascular endothelial growth factor, and was more pronounced in patients with high baseline values. Finally, methylprednisolone reduced the C\u2010reactive protein response 24 h postoperatively; 31.1 (1.1) mg.l\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 68.4 (1.1) mg.l\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p &lt; 0.001. Pre\u2010operative administration of methylprednisolone 125 mg reduced circulating markers of endothelial activation and damage, as well as the systemic inflammatory response (C\u2010reactive protein) early after fast\u2010track total knee arthroplasty. These findings may have a positive effect on surgical outcome, but require studies in major surgery.\n                  <\/jats:p>","DOI":"10.1111\/anae.13983","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T01:42:36Z","timestamp":1501033356000},"page":"1217-1224","source":"Crossref","is-referenced-by-count":41,"title":["The effect of pre\u2010operative methylprednisolone on early endothelial damage after total knee arthroplasty: a randomised, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"72","author":[{"given":"V.","family":"Lindberg\u2010Larsen","sequence":"first","affiliation":[{"name":"Section for Surgical Pathophysiology The Lundbeck Foundation Centre for Fast\u2010Track Hip and Knee Arthroplasty Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Section for Transfusion Medicine Capital Region Blood Bank Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lindberg\u2010Larsen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Copenhagen University Hospital, Bispebjerg and Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Rovsing","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Copenhagen University Hospital, Bispebjerg and Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. I.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Section for Transfusion Medicine Capital Region Blood Bank Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Department of Surgery University of Texas Health Sciences Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology The Lundbeck Foundation Centre for Fast\u2010Track Hip and Knee Arthroplasty Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400605"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.11.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318226113d"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00325.2011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000129669.21649.40"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq137"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0481-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp249"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000181325.08926.9c"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.684852"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12532"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398377"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120914"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.10.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001751"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318164f319"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050541"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-008-0749-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000286984.39328.96"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes505"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1997.tb00735.x"},{"key":"e_1_2_6_24_1","first-page":"3","article-title":"Soluble markers of endothelial cell function","volume":"17","author":"Blann A","year":"1997","journal-title":"Clinical Hemorheology and Microcirculation"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006544"},{"key":"e_1_2_6_26_1","first-page":"440","volume-title":"Practical statistics for medical research","author":"Altman DG","year":"1991"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq333"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.13983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.13983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:24:19Z","timestamp":1761679459000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.13983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/anae.13983"],"URL":"https:\/\/doi.org\/10.1111\/anae.13983","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,26]]}}}