{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:19:48Z","timestamp":1789777188567,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fiona Elizabeth Agnew Trust"},{"name":"Welsh Intensive Care Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Our aim was to prospectively determine the predictive capabilities of\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20101 and\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20103 definitions in the emergency departments and general wards. Patients with National Early Warning Score (NEWS) of 3 or above and suspected or proven infection were enrolled over a 24\u2010h period in 13 Welsh hospitals. The primary outcome measure was mortality within 30 days. Out of the 5422 patients screened, 431 fulfilled inclusion criteria and 380 (88%) were recruited. Using the\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20101 definition, 212 patients had sepsis. When using the\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20103 definitions with Sequential Organ Failure Assessment (SOFA) score \u2265 2, there were 272 septic patients, whereas with quick\n                    <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content>\n                    score \u2265 2, 50 patients were identified. For the prediction of primary outcome,\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20101 criteria had a sensitivity (95%CI) of 65% (54\u201375%) and specificity of 47% (41\u201353%);\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20103 criteria had a sensitivity of 86% (76\u201392%) and specificity of 32% (27\u201338%).\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20103 and\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20101 definitions were associated with a hazard ratio (95%CI) 2.7 (1.5\u20135.6) and 1.6 (1.3\u20132.5), respectively. Scoring system discrimination evaluated by receiver operating characteristic curves was highest for Sequential Organ Failure Assessment score (0.69 (95%CI 0.63\u20130.76)), followed by NEWS (0.58 (0.51\u20130.66)) (p &lt; 0.001). Systemic inflammatory response syndrome criteria (0.55 (0.49\u20130.61)) and quick\n                    <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content>\n                    score (0.56 (0.49\u20130.64)) could not predict outcome. The\n                    <jats:styled-content style=\"fixed-case\">SEPSIS<\/jats:styled-content>\n                    \u20103 definition identified patients with the highest risk. Sequential Organ Failure Assessment score and NEWS were better predictors of poor outcome. The Sequential Organ Failure Assessment score appeared to be the best tool for identifying patients with high risk of death and sepsis\u2010induced organ dysfunction.\n                  <\/jats:p>","DOI":"10.1111\/anae.14062","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T23:12:43Z","timestamp":1510960363000},"page":"195-204","source":"Crossref","is-referenced-by-count":52,"title":["Defining sepsis on the wards: results of a multi\u2010centre point\u2010prevalence study comparing two sepsis definitions"],"prefix":"10.1111","volume":"73","author":[{"given":"T.","family":"Szakmany","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"},{"name":"Anaesthetic Directorate Aneurin Bevan University Health Board Royal Gwent Hospital Newport Gwent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Anaesthetic Department Glan Clywdd Hospital Betsi Cadwaladar University Health Board Bodelwyddan Rhyl UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kopczynska","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Critical Care Directorate University Hospital of Wales Cardiff and Vale University Health Board Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"},{"name":"Critical Care Directorate University Hospital of Wales Cardiff and Vale University Health Board Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kulikouskaya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Al\u2010Hassan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Grother","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"McNulty","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Seal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cains","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vreugdenhil","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Abdimalik","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dennehey","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Beasant","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lazarou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. V.","family":"Vanderpump","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Guerrier Sadler","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Keeling","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Banks","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. W. Y.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine Division of Population Medicine Cardiff University UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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