{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:44:51Z","timestamp":1788371091415,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to explore whether ketamine prevents or exacerbates acute or post\u2010traumatic stress disorders in military trauma patients. We conducted a retrospective study of a database from the French Military Health Service, including all soldiers surviving a war injury in Afghanistan (2010\u20132012). The diagnosis of post\u2010traumatic stress disorder was made by a psychiatrist and patients were analysed according to the presence or absence of this condition. Analysis included the following covariables: age; sex; acute stress disorder; blast injury; associated fatality; brain injury; traumatic amputation; Glasgow coma scale; injury severity score; administered drugs; number of surgical procedures; physical, neurosensory or aesthetic sequelae; and the development chronic pain. Covariables related to post\u2010traumatic and acute stress disorders with a p\u00a0\u2264\u00a00.10 were included in a multivariable logistic regression model. The data from 450 soldiers were identified; 399 survived, of which 274 were analysed. Among these, 98 (36%) suffered from post\u2010traumatic stress disorder and 89 (32%) had received ketamine. Fifty\u2010four patients (55%) in the post\u2010traumatic stress disorder group received ketamine vs. 35 (20%) in the no\n                    <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                    group (p\u00a0&lt;\u00a00.001). The 89 injured soldiers who received ketamine had a median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    [range]) injury severity score of 5 (3\u201313 [1\u201326]) vs. 3 (2\u20134 [1\u20136] in the 185 patients who did not (p\u00a0&lt;\u00a00.001). At multivariable analysis, only acute stress disorder and total number of surgical procedures were independently associated with the development of post\u2010traumatic stress disorder. In this retrospective study, ketamine administration was not a risk factor for the development of post\u2010traumatic stress disorder in the military trauma setting.\n                  <\/jats:p>","DOI":"10.1111\/anae.14079","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T06:06:37Z","timestamp":1507010797000},"page":"1476-1483","source":"Crossref","is-referenced-by-count":32,"title":["A retrospective study of ketamine administration and the development of acute or post\u2010traumatic stress disorder in 274 war\u2010wounded soldiers"],"prefix":"10.1111","volume":"72","author":[{"given":"G.","family":"Mion","sequence":"first","affiliation":[{"name":"Anaesthesia Department Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Le Masson","sequence":"additional","affiliation":[{"name":"French Navy Medical Service Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Granier","sequence":"additional","affiliation":[{"name":"Psychiatry Department Paul Guiraud Hospital Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Burn Center Percy Military Teaching Hospital Clamart 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