{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:00:28Z","timestamp":1790859628574,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T00:00:00Z","timestamp":1512691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Achieving successful treatment of postoperative pain remains a challenge. Recently, a sufentanil sublingual tablet system has been developed for treatment of moderate\u2010to\u2010severe postoperative pain. The phenylpiperidine sufentanil is a potent analgesic that rapidly crosses the blood\u2013brain barrier and selectively activates central \u03bc\u2010opioid receptors. The system makes use of a hand\u2010held dispenser system, which contains forty 15\u2010\u03bcg sufentanil sublingual micro\u2010tablets. The patient can release one tablet at 20\u2010min intervals using a unique radiofrequency adhesive tag, which is wrapped around the patient's thumb. In this review, the authors discuss the pharmacology of sublingual sufentanil with reference to its suitability in the treatment of postoperative pain, the current evidence for the sublingual sufentanil system in postoperative pain treatment, and advantages and limitations of the sublingual system. We conclude that sufentanil is suited for the transmucosal route due to its pharmacokinetic profile, including rapid onset, absence of active metabolites and low tissue accumulation. The efficacy and safety of the sufentanil sublingual tablet system has been shown in over 600 patients in a limited set of studies; further independent studies are required to determine the position of the system among other forms of postoperative pain treatment. We conclude that the sublingual sufentanil tablet system allows effective pain relief, and allows patients to control their own pain relief and early postoperative mobility.<\/jats:p>","DOI":"10.1111\/anae.14132","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T07:02:44Z","timestamp":1512716564000},"page":"231-237","source":"Crossref","is-referenced-by-count":56,"title":["Pharmacokinetics and pharmacodynamics of sublingual sufentanil for postoperative pain management"],"prefix":"10.1111","volume":"73","author":[{"given":"T.","family":"van de Donk","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ward","sequence":"additional","affiliation":[{"name":"Pain and Anaesthesia Research Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Langford","sequence":"additional","affiliation":[{"name":"Pain and Anaesthesia Research Centre St Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dahan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143508"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021507003031"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021503"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.06.028"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1213\/01.ANE.0000068822.10113.9E","article-title":"Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged","volume":"97","author":"Apfelbaum JL","year":"2003","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_6_7_1","first-page":"1551","article-title":"Sufentanil, a very potent and extremely safe intravenous morphine\u2010like compound in mice, rats and dogs","volume":"26","author":"Niemegeers CJ","year":"1976","journal-title":"Arzneimittel\u2010Forschung"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000746"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000152"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12238"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.11.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198411000-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241110-00001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199203000-00003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199101000-00007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.975202"},{"key":"e_1_2_6_17_1","first-page":"166","volume-title":"Opioids in pain control. Basic and clinical aspects","author":"Bernards CM","year":"1999"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.11.59"},{"key":"e_1_2_6_19_1","first-page":"505","volume-title":"Clinical anesthesia","author":"Dahan A","year":"2017"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199601000-00031"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31821d8ac1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200401000-00021"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2005.04503.x"},{"key":"e_1_2_6_25_1","unstructured":"National Institute for Health and Care Excellence.ESNM71 Moderate to severe acute post\u2010operative pain: sufentanil sublingual tablet system.2016.https:\/\/www.nice.org.uk\/advice\/esnm71\/chapter\/key-points-from-the-evidence(accessed 08\/10\/2017)."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.01.012"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:28:51Z","timestamp":1761683331000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/anae.14132"],"URL":"https:\/\/doi.org\/10.1111\/anae.14132","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,8]]}}}