{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:11:06Z","timestamp":1787847066807,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006392","name":"Centre Hospitalier Universitaire Vaudois","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Long\u2010acting neuraxial opioids provide excellent analgesia after surgery, but are associated with higher rates of postoperative nausea and vomiting. Dexamethasone effectively prevents postoperative nausea and vomiting after general anaesthesia, but its value in patients receiving long\u2010acting neuraxial opioids is undetermined. Therefore, the objective of this meta\u2010analysis was to assess the prophylactic anti\u2010emetic efficacy of intravenous (i.v.) dexamethasone in this population. The study methodology followed the\n                    <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                    statement guidelines. The primary outcome was the need for rescue anti\u2010emetics during the first 24 postoperative hours, analysed according to the dose of dexamethasone (low\u2010dose 2.5\u20135.0 mg; intermediate dose 6.0\u201310.0 mg), timing of administration (beginning or end of surgery) and route of long\u2010acting opioid administration (intrathecal or epidural). Additionally, the rates of complications (restlessness, infection, hyperglycaemia) were sought. Thirteen trials were identified, representing a total of 1111 patients. When compared with placebo, intravenous dexamethasone reduced the need for rescue anti\u2010emetics (risk ratio (95%CI) 0.44 (0.35\u20130.56); I\n                    <jats:sup>2<\/jats:sup>\n                    = 43%; p &lt; 0.00001; quality of\n                    <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content>\n                    evidence: moderate), without differences between dexamethasone doses (p for sub\u2010group difference = 0.67), timing of administration (p for sub\u2010group difference = 0.32) or route of long\u2010acting opioid (p for sub\u2010group difference = 0.10). No patients developed infection or restlessness among trials that sought these complications. No trial measured blood glucose levels. In conclusion, there is enough evidence to state that intravenous dexamethasone provides effective anti\u2010emetic prophylaxis during the first 24 postoperative hours in patients who receive long\u2010acting neuraxial opioids.\n                  <\/jats:p>","DOI":"10.1111\/anae.14166","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T06:36:57Z","timestamp":1512974217000},"page":"480-489","source":"Crossref","is-referenced-by-count":34,"title":["Intravenous dexamethasone for prophylaxis of postoperative nausea and vomiting after administration of long\u2010acting neuraxial opioids: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"73","author":[{"given":"S.","family":"Grape","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Valais Hospital Sion Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Usmanova","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Valais Hospital Sion Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Kirkham","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Toronto Western Hospital University of Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.11.028"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000128"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.114057"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200103000-00036"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg120"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.6.865"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318247f628"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13108"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v14i2.23"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.889597"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.10.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12823"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13347"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13568"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13334"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13832"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13355"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13649"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13765"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13730"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328356676b"},{"key":"e_1_2_6_29_1","first-page":"254","article-title":"The effect of intravenous dexamethasone on postoperative pain, nausea and vomiting after intrathecal pethidine and bupivacaine in lower limb orthopedic surgery","volume":"19","author":"Kadur SN","year":"2015","journal-title":"Anaesthesia, Pain and Intensive Care"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000257926.07491.55"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(01)00345-2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199907000-00020"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019733"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200203000-00050"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2006.11.004"},{"key":"e_1_2_6_36_1","first-page":"758","article-title":"Effects of dexamethasone on epidural morphine\u2010related nausea and vomiting","volume":"22","author":"Wu YW","year":"2002","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31822a24c2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13544"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:32:06Z","timestamp":1761676326000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/anae.14166"],"URL":"https:\/\/doi.org\/10.1111\/anae.14166","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}