{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T19:07:14Z","timestamp":1767035234474,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"departmental funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sugammadex more rapidly and reliably reverses rocuronium\u2010induced neuromuscular block compared with neostigmine, but it is not known if subsequent patient outcomes, including nausea, vomiting and other aspects of recovery are modified. In this study, we compared the recovery characteristics of sugammadex and neostigmine\/glycopyrrolate following reversal of neuromuscular block. This was a single\u2010centre, randomised, blinded, parallel\u2010group clinical trial in women undergoing elective day\u2010surgical laparoscopic gynaecological surgery, with a standardised general anaesthesia regimen that included rocuronium. Neuromuscular block was reversed with either sugammadex 2 mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    or neostigmine 40 \u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    and glycopyrrolate 400 \u03bcg. The primary outcome was the incidence of nausea and vomiting during the first six postoperative hours. Secondary outcomes included other measures of postoperative recovery such as patient symptoms and recovery scores. Three\u2010hundred and four women were analysed by intention\u2010to\u2010treat (sugammadex n = 151, neostigmine n = 153), which included four major protocol violations. There was no significant difference between sugammadex and neostigmine groups in the incidence of early nausea and vomiting (49.0% vs. 51.0%, respectively;\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    0.92, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    0.59\u20131.45; p = 0.731). Double vision (11.5% vs. 20.0%; p = 0.044) and dry mouth (71.6% vs. 85.5%; p = 0.003) were less common after sugammadex. Sedation scores at 2 h were also lower after sugammadex (median (IQR [range]) 0 (0\u20103 [0\u201010]) vs. 2 (0\u20104.[0\u201010]); p = 0.021). Twenty\u2010four\u2010hour recovery scores were not significantly different between groups. Reversal with sugammadex in this patient population did not reduce postoperative nausea or vomiting compared with neostigmine\/glycopyrrolate.\n                  <\/jats:p>","DOI":"10.1111\/anae.14174","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T01:38:50Z","timestamp":1512610730000},"page":"340-347","source":"Crossref","is-referenced-by-count":36,"title":["Recovery characteristics of patients receiving either sugammadex or neostigmine and glycopyrrolate for reversal of neuromuscular block: a randomised controlled trial"],"prefix":"10.1111","volume":"73","author":[{"given":"M. J.","family":"Paech","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine King Edward Memorial Hospital Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Stoke Mandeville Hospital Aylesbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Baber","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Sir Charles Gairdner Hospital Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Nathan","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13277"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq269"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1504300104"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.3.379"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000180992.76743.C9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes276"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2014.08.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12389"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12813"},{"key":"e_1_2_6_12_1","first-page":"147","article-title":"Comparison of the effects of sugammadex and neostigmine on postoperative nausea and vomiting","volume":"67","author":"Yagan O","year":"2017","journal-title":"Revista Brasileira de Anestesiologia"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000049"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0002800304"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9547-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.2.234"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep370"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07197.x"},{"key":"e_1_2_6_20_1","first-page":"CD007362","article-title":"Sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade","volume":"4","author":"Abrishami A","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer142"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000757"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000151159.55655.CB"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.03.010"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:05:15Z","timestamp":1761678315000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/anae.14174"],"URL":"https:\/\/doi.org\/10.1111\/anae.14174","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"type":"print","value":"0003-2409"},{"type":"electronic","value":"1365-2044"}],"subject":[],"published":{"date-parts":[[2017,12,7]]}}}