{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:59Z","timestamp":1787013839241,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Treatment of post\u2010spinal hypotension during caesarean section assumes special concern in pre\u2010eclamptic patients due to a compromised fetoplacental circulation and increased risk of placental hypoperfusion. Phenylephrine and ephedrine are the most commonly used vasopressors, although the best choice is still not clear. We studied 80 pre\u2010eclamptic women with a singleton pregnancy who underwent caesarean section with spinal anaesthesia, and who developed hypotension defined as a decrease in systolic arterial pressure \u2265 20% from baseline or absolute value &lt; 100 mmHg. Women were randomly allocated to receive phenylephrine 50 \u03bcg or ephedrine 4 mg boluses for treatment of hypotension. Blood pressure changes following vasopressor administration were similar in both groups, but heart rate remained higher after ephedrine at all time\u2010points. The primary outcome measure of umbilical artery\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    was 7.26 (0.11) in the phenylephrine group and 7.25 (0.09) in the ephedrine group (p = 0.86). The incidence of neonatal acidosis (umbilical artery\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    &lt; 7.20) was 9 (22.5%) in the phenylephrine group and 11 (27.5%) in the ephedrine group (p = 0.80). Other secondary outcome measures were comparable. In conclusion, phenylephrine 50 \u03bcg and ephedrine 4 mg, administered as intravenous boluses to treat post\u2010spinal hypotension during caesarean section in pre\u2010eclamptic patients, resulted in similar fetal acid\u2010base values, were equally effective in treating hypotension and were associated with good maternal and neonatal outcome.\n                  <\/jats:p>","DOI":"10.1111\/anae.14268","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T01:46:37Z","timestamp":1520559997000},"page":"839-846","source":"Crossref","is-referenced-by-count":28,"title":["Randomised double\u2010blind comparison of bolus phenylephrine or ephedrine for treatment of hypotension in women with pre\u2010eclampsia undergoing caesarean section"],"prefix":"10.1111","volume":"73","author":[{"given":"M.","family":"Mohta","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Duggal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. T.","family":"Chilkoti","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32832a1d05"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000073610.23885.F2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000175229.98493.2B"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.02058-5.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00028"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200212000-00034"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328337ffc6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14080"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei305"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000311153.84687.c7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1687-7934.133444"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1159953"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14040"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2017.08.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2009.02.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3283530d62"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818065bc"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14114"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2004.08.002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000160535.95678.34"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182373a3e"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei265"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200309000-00010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00139-I"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70083-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00347-0"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:10:09Z","timestamp":1761700209000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/anae.14268"],"URL":"https:\/\/doi.org\/10.1111\/anae.14268","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]}}}