{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:18:54Z","timestamp":1785295134398,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T00:00:00Z","timestamp":1527897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006392","name":"Centre Hospitalier Universitaire Vaudois","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Animal data have demonstrated increased block duration after local anaesthetic injections in diabetic rat models. Whether the same is true in humans is currently undefined. We, therefore, undertook this prospective cohort study to test the hypothesis that type\u20102 diabetic patients suffering from diabetic peripheral neuropathy would have increased block duration after ultrasound\u2010guided popliteal sciatic nerve block when compared with patients without neuropathy. Thirty\u2010three type\u20102 diabetic patients with neuropathy and 23 non\u2010diabetic control patients, scheduled for fore\u2010foot surgery, were included prospectively. All patients received an ultrasound\u2010guided popliteal sciatic nerve block with a 30 ml 1:1 mixture of lidocaine 1% and bupivacaine 0.5%. The primary outcome was time to first opioid request after block procedure. Secondary outcomes included the time to onset of sensory blockade, and pain score at rest on postoperative day 1 (numeric rating scale 0\u201310). These outcomes were analysed using an accelerated failure time regression model. Patients in the diabetic peripheral neuropathy group had significantly prolonged median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    [range]) time to first opioid request (diabetic peripheral neuropathy group 1440 (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    1140\u20131440 [180\u20131440]) min vs. control group 710 (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    420\u20131200 [150\u20131440] min, p = 0.0004). Diabetic peripheral neuropathy patients had a time ratio of 1.57 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    1.10\u20132.23, p &lt; 0.01), experienced a 59% shorter time to onset of sensory blockade (median time ratio 0.41 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    0.28\u20130.59), p &lt; 0.0001) and had lower median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    [range]) pain scores at rest on postoperative day 1 (diabetic peripheral neuropathy group 0 (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    0\u20131 [0\u20135]) vs. control group 3 (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    0\u20135 [0\u20139]), p = 0.001). In conclusion, after an ultrasound\u2010guided popliteal sciatic nerve block, patients with diabetic peripheral neuropathy demonstrated reduced time to onset of sensory blockade, with increased time to first opioid request when compared with patients without neuropathy.\n                  <\/jats:p>","DOI":"10.1111\/anae.14347","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T03:08:55Z","timestamp":1527908935000},"page":"1110-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of peripheral nerve blockade characteristics between non\u2010diabetic patients and patients suffering from diabetic neuropathy: a prospective cohort study"],"prefix":"10.1111","volume":"73","author":[{"given":"M.","family":"Baeriswyl","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Taff\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine (IUMSP) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Kirkham","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Toronto Western Hospital University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bathory","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rancati","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Crevoisier","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cherix","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70065-0"},{"key":"e_1_2_6_3_1","unstructured":"MargolisDJ MalayDS HoffstadOJ et al.Prevalence of diabetes diabetic foot ulcer and lower extremity amputation among Medicare beneficiaries 2006 to 2008: Data Points #1. 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