{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T21:39:30Z","timestamp":1772746770959,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The peri\u2010operative use of angiotensin\u2010converting enzyme inhibitors or angiotensin\u20102 receptor blockers is thought to be associated with an increased risk of postoperative acute kidney injury. To reduce this risk, these agents are commonly withheld during the peri\u2010operative period. This study aimed to investigate if withholding angiotensin\u2010converting enzyme inhibitors or angiotensin\u20102 receptor blockers peri\u2010operatively reduces the risk of acute kidney injury following major non\u2010cardiac surgery. Patients undergoing elective major surgery on the gastrointestinal tract and\/or the liver were eligible for inclusion in this prospective study. The primary outcome was the development of acute kidney injury within seven days of operation. Adjusted multi\u2010level models were used to account for centre\u2010level effects and propensity score matching was used to reduce the effects of selection bias between treatment groups. A total of 949 patients were included from 160 centres across the UK and Republic of Ireland. From this population, 573 (60.4%) patients had their angiotensin\u2010converting enzyme inhibitors or angiotensin\u20102 receptor blockers withheld during the peri\u2010operative period. One hundred and seventy\u2010five (18.4%) patients developed acute kidney injury; there was no difference in the incidence of acute kidney injury between patients who had their angiotensin\u2010converting enzyme inhibitors or angiotensin\u20102 receptor blockers continued or withheld (107 (18.7%) vs. 68 (18.1%), respectively; p = 0.914). Following propensity matching, withholding angiotensin\u2010converting enzyme inhibitors or angiotensin\u20102 receptor blockers did not demonstrate a protective effect against the development of postoperative acute kidney injury (OR (95%CI) 0.89 (0.58\u20131.34); p = 0.567).<\/jats:p>","DOI":"10.1111\/anae.14349","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T06:28:00Z","timestamp":1531117680000},"page":"1214-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Association between peri\u2010operative angiotensin\u2010converting enzyme inhibitors and angiotensin\u20102 receptor blockers and acute kidney injury in major elective non\u2010cardiac surgery: a multicentre, prospective cohort study"],"prefix":"10.1111","volume":"73","author":[{"name":"STARSurg Collaborative","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4157-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev380"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.04.006"},{"key":"e_1_2_6_5_1","first-page":"5","article-title":"The association between atherosclerotic renal artery stenosis and acute kidney injury in patients undergoing cardiac surgery","volume":"8","author":"Yang J","year":"2013","journal-title":"PLoS ONE"},{"key":"e_1_2_6_6_1","first-page":"251","article-title":"Diuretics in acute kidney injury","volume":"75","author":"Karajala V","year":"2009","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.101"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8525"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13348"},{"key":"e_1_2_6_10_1","unstructured":"EBM DataLab University of Oxford.OpenPrescribing.net.2017.https:\/\/openprescribing.net(accessed 14\/10\/2017)."},{"key":"e_1_2_6_11_1","unstructured":"National Institute for Health and Clinical Excellence (NICE).Hypertension in adults\u202f: diagnosis and management.2016. NICE Guideline CG127https:\/\/www.nice.org.uk\/guidance\/cg127(accessed 28\/09\/2017)."},{"key":"e_1_2_6_12_1","unstructured":"National Institute for Health and Care Excellence (NICE).Chronic kidney disease in adults\u202f: assessment and management.2015. NICE Guideline CG182https:\/\/www.nice.org.uk\/guidance\/cg182(accessed 28\/09\/2017)."},{"key":"e_1_2_6_13_1","first-page":"CD009210","article-title":"Perioperative angiotensin\u2010converting enzyme inhibitors or angiotensin II type 1 receptor blockers for preventing mortality and morbidity in adults","volume":"1","author":"Zou Z","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.04.019"},{"key":"e_1_2_6_15_1","first-page":"1","article-title":"Outcomes After Kidney injury in Surgery (OAKS): protocol for a multicentre, observational cohort study of acute kidney injury following major gastrointestinal and liver surgery","volume":"6","author":"STARSurg Collaborative","year":"2016","journal-title":"British Medical Journal Open"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_6_17_1","first-page":"s1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"The International Society of Nephrology","year":"2012","journal-title":"Kidney International"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001404"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078465"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7894"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000765"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.04.018"},{"key":"e_1_2_6_25_1","first-page":"133","article-title":"Pathophysiology and management of angiotensin\u2010converting enzyme inhibitor\u2010associated refractory hypotension during the perioperative period","volume":"81","author":"Thoma A","year":"2013","journal-title":"American Association of Nurse Anesthetists Journal"},{"key":"e_1_2_6_26_1","unstructured":"ShiffermillerJ.Chronic angiotensin converting enzyme inhibitors in intermediate risk surgery. 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ClinicalTrials.gov 2017.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02096406(accessed 12\/11\/2017)."},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/ndt\/gfv415","article-title":"Risk prediction models for acute kidney injury following major noncardiac surgery: systematic review","volume":"31","author":"Wilson T","year":"2016","journal-title":"Nephrology Dialysis Transplantation"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.07.022"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.14349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:36:47Z","timestamp":1761694607000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/anae.14349"],"URL":"https:\/\/doi.org\/10.1111\/anae.14349","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"assertion":[{"value":"2018-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}