{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:00:49Z","timestamp":1761681649318,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Leakage of colonised oropharyngeal secretions across the tracheal tube cuff may cause iatrogenic pulmonary infection. We studied a novel \u2018add\u2010on\u2019 cuff, which can be inserted over an existing tracheal tube and advanced into the subglottic region. The physical properties of the novel silicone cuff (BronchoGuard, Ciel Medical,\n                    <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>\n                    ) were evaluated in comparison with the Hi\u2010Lo\n                    <jats:sup>\u00ae<\/jats:sup>\n                    tracheal tube. In a bench study, we identified saline inflation volumes required to transmit pressures between 15 and 30\u00a0cmH\n                    <jats:sub>2<\/jats:sub>\n                    O against artificial tracheas of 18, 20 and 22\u00a0mm internal diameter. We computed cuff compliance, and minimal inflation volume to achieve air sealing during mechanical ventilation. Finally, we compared the leakage flow rate of artificial saliva across the novel cuff. On average, the mean (\n                    <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                    ) inflation volumes necessary to transmit tracheal pressures of 15, 20, 25 and 30\u00a0cmH\n                    <jats:sub>2<\/jats:sub>\n                    O were 4.1 (2.2), 4.4 (2.3), 4.6 (2.4) and 4.8 (2.4) ml for the novel cuff and 7.7 (2.5), 8.0 (2.6), 8.4 (2.6) and 8.7 (2.7) ml for the Hi\u2010Lo tube, respectively (p\u00a0&lt;\u00a00.001). The minimal inflation volumes to achieve air sealing were 3.8 (0.9) and 10.5 (2.1) ml (p\u00a0&lt;\u00a00.001), which resulted in transmitted tracheal pressures of 8.3 (9.8) and 27.6 (34.8)\u00a0cmH\n                    <jats:sub>2<\/jats:sub>\n                    O (p\u00a0&lt;\u00a00.001). Compliance was 0.026 (0.004) and 0.616 (0.324) ml.cmH\n                    <jats:sub>2<\/jats:sub>\n                    0\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively (p\u00a0&lt;\u00a00.001). Although massive leak was found when the novel cuff transmitted pressures \u2264\u00a020\u00a0cmH\n                    <jats:sub>2<\/jats:sub>\n                    O against the trachea, leakage was avoided with pressures \u2265\u00a025\u00a0cmH\n                    <jats:sub>2<\/jats:sub>\n                    O, owing to optimal contact between the cuff and the tracheal wall. In contrast, the standard cuff consistently leaked irrespective of the pressure. We conclude that the novel cuff has advantageous properties that warrant clinical corroboration.\n                  <\/jats:p>","DOI":"10.1111\/anae.14413","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T23:43:35Z","timestamp":1539042215000},"page":"1372-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In\u2010vitro analysis of a novel \u2018add\u2010on\u2019 silicone cuff to improve sealing properties of tracheal tubes"],"prefix":"10.1111","volume":"73","author":[{"given":"G.","family":"Li Bassi","sequence":"first","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chiurazzi","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Travierso","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Italy"},{"name":"Internal Medicine Department Respiratory Unit and Adult Cystic Fibrosis Center Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Battaglini","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Motos","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Meli","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care Medicine Ospedale San Paolo Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Marti","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. T.","family":"Ranzani","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Italy"},{"name":"Internal Medicine Department Respiratory Unit and Adult Cystic Fibrosis Center Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chiumello","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care Medicine Ospedale San Paolo Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department Hospital Cl\u00ednic Thorax Institute Pneumology Department and University of Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biomedica En Red\u2010 Enfermedades Respiratorias (CIBERES) Barcelona 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