{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:55:54Z","timestamp":1792205754345,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Coagulopathy in patients with traumatic brain injury is associated with an increase in morbidity and mortality. Although timely and aggressive treatment of coagulopathy is of paramount importance, excessive transfusion of blood products has been linked with poor long\u2010term outcomes in patients with traumatic brain injury. A point\u2010of\u2010care thromboelastometric\u2010guided algorithm could assist in creating a more individually tailored approach to each patient. The aim of this study was to evaluate the feasibility of implementing a thromboelastometric\u2010guided algorithm in centres that were formerly na\u00efve to thromboelastometry. Hence, we developed such an algorithm and provided training to four centres across Europe to direct the haemostatic management of patients with severe traumatic brain injury. The primary outcome was adherence to the algorithm and timing of the availability of relevant results. Thirty\u2010two patients were included in the study. Complete adherence to the algorithm was observed in 20 out of 32 cases. The availability of thromboelastometric results after hospital admission was reported significantly earlier than conventional coagulation tests (median (\n                    <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                    [range]) 33 (20\u201340 [14\u2013250]) min vs. 71 (51\u2013101 [32\u2013290]) min; p\u00a0=\u00a00.037). Although only 5 out of 32 patients had abnormalities of conventional coagulation tests, 21 out of 32 patients had a coagulopathic baseline thromboelastometric trace. Implementing a thromboelastometric\u2010guided algorithm for the haemostatic therapy of traumatic brain injury is feasible in centres formerly na\u00efve to this technology and may lead to more rapid and precise coagulation management. Further large\u2010scale studies are warranted to confirm the results of this pilot trial and evaluate clinical outcomes.\n                  <\/jats:p>","DOI":"10.1111\/anae.14670","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T06:58:54Z","timestamp":1556521134000},"page":"883-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Protocolised thromboelastometric\u2010guided haemostatic management in patients with traumatic brain injury: a pilot study"],"prefix":"10.1111","volume":"74","author":[{"given":"J.","family":"Gratz","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Critical Care and Pain Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"G\u00fcting","sequence":"additional","affiliation":[{"name":"Institute for Research in Operative Medicine University Witten\/Herdecke Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thorn","sequence":"additional","affiliation":[{"name":"Monash University Melbourne School of Public Health and Preventive Medicine Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Brazinova","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology Faculty of Medicine Comenius University Bratislava Bratislava Slokak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"G\u00f6rlinger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine University Hospital Essen Germany"},{"name":"TEM Innovations GmbH Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Institute for Research in Operative Medicine University Witten\/Herdecke Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sch\u00f6chl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine AUVA Trauma Centre Salzburg Academic Teaching Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology AUVA Trauma Research Centre Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Stanworth","sequence":"additional","affiliation":[{"name":"Department of Haematology Radcliffe Department of Medicine Oxford University Hospitals NHS Foundation Trust University of Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maegele","sequence":"additional","affiliation":[{"name":"Institute for Research in Operative Medicine University Witten\/Herdecke Cologne Germany"},{"name":"Department of Traumatology and 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