{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:32:36Z","timestamp":1787056356900,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Phenylephrine is currently the vasopressor of choice during elective caesarean section, but it can cause reflex bradycardia. Noradrenaline, a potent \u03b1\u2010agonist and weak \u03b2\u2010agonist, may be associated with a lower incidence of bradycardia. However, comparative information is limited. This double\u2010blind randomised controlled trial compared the effects of 100\u00a0\u03bcg phenylephrine and 5\u00a0\u03bcg noradrenaline administered as boluses for the treatment of postspinal hypotension during elective caesarean section in women with an uncomplicated singleton pregnancy. Hypotension was defined as a decrease of \u2265\u00a020% from baseline systolic arterial pressure, or an absolute value &lt;\u00a0100\u00a0mmHg. Ninety women were included in the study. The primary outcome was the incidence of maternal bradycardia &lt;\u00a060\u00a0beats.min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . There was no difference in the incidence of bradycardia (37.8% with phenylephrine vs. 22.2% with noradrenaline; p\u00a0=\u00a00.167), number of hypotensive episodes, number of boluses required to treat the first hypotensive episode or reactive hypertension. The total number of boluses used was higher in the phenylephrine group (p\u00a0=\u00a00.01). Maternal heart rate at 1\u00a0min after vasopressor administration was non\u2010significantly lower using phenylephrine vs. noradrenaline (p\u00a0=\u00a00.034, considering p\u00a0&lt;\u00a00.01 as statistically significant). The umbilical artery\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    was higher using phenylephrine than with noradrenaline (p\u00a0=\u00a00.034). In conclusion, both vasopressors reversed postspinal hypotension without a statistically significant difference in maternal bradycardia. However, in view of the lower umbilical artery\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    when using noradrenaline, further research is warranted to study its placental transfer and fetal metabolic effects.\n                  <\/jats:p>","DOI":"10.1111\/anae.14675","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T01:17:40Z","timestamp":1556759860000},"page":"850-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["A randomised controlled trial of phenylephrine and noradrenaline boluses for treatment of postspinal hypotension during elective caesarean section"],"prefix":"10.1111","volume":"74","author":[{"given":"M.","family":"Mohta","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. T.","family":"Chilkoti","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Delhi Cancer Registry, Dr. BRA IRCH All India Institute of Medical Sciences Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14080"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000192816.22989.ba"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f2eae1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000601"},{"key":"e_1_2_6_6_1","first-page":"714966","article-title":"Comparison of norepinephrine and cafedrine\/theodrenaline regimens for maintaining maternal blood pressure during spinal anaesthesia for caesarean section","volume":"2015","author":"Hoyme M","year":"2015","journal-title":"Obstetrics and Gynecology: An International Journal"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001880"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002243"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2016.08.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001846"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1504300111"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181b437e0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.1.54"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181b160a3"},{"key":"e_1_2_6_15_1","first-page":"19","article-title":"The effect of parturition on umbilical blood plasma levels of norepinephrine","volume":"61","author":"Puolakka J","year":"1983","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90729-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(64)90055-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90182-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199308000-00004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199305000-00005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2018.12.002"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.14675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:04:27Z","timestamp":1761681867000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/anae.14675"],"URL":"https:\/\/doi.org\/10.1111\/anae.14675","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2019-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}