{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:02:22Z","timestamp":1775743342275,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Propofol is the most commonly administered intravenous agent for anaesthesia in children. However, there are concerns that the emulsified preparation may not be safe in children with an allergy to egg, peanut, soybean or other legumes. We conducted a retrospective study of children with immunologically confirmed egg, peanut, soybean or legume allergy and who underwent general anaesthesia at Princess Margaret Hospital for Children between 2005 and 2015. We extracted details regarding allergy diagnosis, each anaesthetic administered and any adverse events or signs of an allergic reaction in the peri\u2010operative period. A convenience sample of patients without any known food allergies was identified from our prospective anaesthesia research database and acted as a control group. We identified 304 food\u2010allergic children and 649 procedures where propofol was administered. Of these, 201 (66%) had an egg allergy, 226 (74%) had a peanut allergy, 28 (9%) had a soybean allergy and 12 (4%) had a legume allergy. These were compared with 892 allergy\u2010free patients who were exposed to propofol. In 10 (3%) allergy patients and 124 (14%) allergy\u2010free patients, criteria for a possible allergic reaction were met. In nine of the food\u2010allergic children and in all the controls valid non\u2010allergic explanations for the clinical symptoms were found. One likely mild allergic reaction was experienced by a child with a previous history of intralipid allergy. We conclude that genuine serious allergic reaction to propofol is rare and is not reliably predicted by a history of food allergy.<\/jats:p>","DOI":"10.1111\/anae.14693","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T09:42:44Z","timestamp":1557567764000},"page":"1252-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Propofol use in children with allergies to egg, peanut, soybean or other legumes"],"prefix":"10.1111","volume":"74","author":[{"given":"D. L.","family":"Sommerfield","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Pain Management Perth Children's Hospital Perth WA Australia"},{"name":"Medical School The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia Perth WA Australia"},{"name":"Department of Paediatric Clinical Immunology Perth Children's Hospital Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management Perth Children's Hospital Perth WA Australia"},{"name":"Medical School The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. F. 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