{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:31:49Z","timestamp":1761669109608,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Association of Anaesthetists","award":["ACF-2016-09-011"],"award-info":[{"award-number":["ACF-2016-09-011"]}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The measurement of extravascular lung water is a relatively new technology which has not yet been well validated as a clinically useful tool. We studied its utility in patients undergoing pulmonary endarterectomy as they frequently suffer reperfusion lung injury and associated oedematous lungs. Such patients are therefore ideal for evaluating this new monitor. We performed a prospective observational cohort study during which extravascular lung water index measurements were taken before and immediately after surgery and postoperatively in intensive care. Data were analysed for 57 patients; 21 patients (37%) experienced severe reperfusion lung injury. The first extravascular lung water index measurement after cardiopulmonary bypass failed to predict severe reperfusion lung injury, area under the receiver operating characteristic curve 0.59 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    0.44\u20130.74). On intensive care, extravascular lung water index correlated most strongly at 36\u00a0h, area under the receiver operating characteristic curve 0.90 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    0.80\u20131.00). Peri\u2010operative extravascular lung water index is not a useful measure to predict severe reperfusion lung injury after pulmonary endarterectomy, however, it does allow monitoring and measurement during the postoperative period. This study implies that extravascular lung water index can be used to directly assess pulmonary fluid overload and that monitoring patients by measuring extravascular lung water index during their intensive care stay is useful and correlates with their clinical course. This may allow directed, pre\u2010empted therapy to attenuate the effects and improve patient outcomes and should prompt further studies.\n                  <\/jats:p>","DOI":"10.1111\/anae.14744","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T01:22:55Z","timestamp":1562289775000},"page":"1282-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Measurement of extravascular lung water to diagnose severe reperfusion lung injury following pulmonary endarterectomy: a prospective cohort clinical validation study"],"prefix":"10.1111","volume":"74","author":[{"given":"A. G.","family":"Butchart","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care Medicine Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zochios","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine University Hospitals Birmingham National Health Service Foundation Trust Queen Elizabeth Hospital Birmingham University of Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Villar","sequence":"additional","affiliation":[{"name":"MRC Biostatistics Unit University of Cambridge School of Clinical Medicine Cambridge Institute of Public Health UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care Medicine Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care Medicine Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care Medicine Royal Papworth Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019470"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00058112"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2639"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.07.033"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00116-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000130000.15786.82"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.6.2080"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3025"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01005.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000295314.01232.BE"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181743eeb"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000087799.85495.8A"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31826ab377"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.03.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015265"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10599"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13964"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9332"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050043"},{"key":"e_1_2_6_23_1","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin Definition","volume":"307","author":"Definition Task Force ARDS","year":"2012","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000115)19:1<61::AID-SIM297>3.0.CO;2-A"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0258(20000830)19:16<2115::AID-SIM529>3.0.CO;2-M"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1302OC"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000765"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002259"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.14744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.14744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:23:41Z","timestamp":1761668621000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/anae.14744"],"URL":"https:\/\/doi.org\/10.1111\/anae.14744","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"type":"print","value":"0003-2409"},{"type":"electronic","value":"1365-2044"}],"subject":[],"published":{"date-parts":[[2019,7,4]]},"assertion":[{"value":"2019-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}