{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:07:01Z","timestamp":1782500821699,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102019\u20100073"],"award-info":[{"award-number":["6\u20102019\u20100073"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Postoperative nausea and vomiting is the most common side\u2010effect of opioid\u2010based intravenous patient\u2010controlled analgesia. Apfel's simplified risk score is popular but it has some limitations. We developed and validated a dynamic predictive model for nausea or vomiting up to 48 postoperative hours, available as an online web application. Fentanyl was used by 22,144 adult patients for analgesia after non\u2010cardiac surgery under general anaesthesia: we randomly divided them into development (80%) and validation (20%) cohorts, repeated 100 times. We used linear discriminant analysis to select variables for multivariate logistic regression. The incidences of postoperative nausea or vomiting were: 0\u201348\u00a0h, 5691\/22,144 (26%); 0\u20136\u00a0h, 2749\/22,144 (12%); 6\u201312\u00a0h, 2687\/22,144 (12%); 12\u201318\u00a0h, 2624\/22,144 (12%); 18\u201324\u00a0h, 1884\/22,144 (9%); and 24\u201348\u00a0h, 1082\/22,144 (5%). The median (95%CI) area under the receiver operating characteristic curve was 0.72 (0.71\u20130.73) up to 48 postoperative hours compared with 0.65 (0.64\u20130.66) for the Apfel model, p\u00a0&lt;\u00a00.001. The equivalent areas for 0\u20136\u00a0h, 6\u201312\u00a0h, 12\u201318\u00a0h, 18\u201324\u00a0h and 24\u201348\u00a0h were: 0.70 (0.69\u20130.72); 0.71 (0.69\u20130.73); 0.69 (0.68\u20130.71); 0.70 (0.67\u20130.72); and 0.69 (0.66\u20130.71), respectively. Our web application allows clinicians to calculate incidences of nausea and vomiting in patients receiving intravenous fentanyl for patient\u2010controlled analgesia.<\/jats:p>","DOI":"10.1111\/anae.14849","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T03:03:45Z","timestamp":1568775825000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dynamic predictive model for postoperative nausea and vomiting for intravenous fentanyl patient\u2010controlled analgesia"],"prefix":"10.1111","volume":"75","author":[{"given":"D.","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Pharmacology Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Gangnam Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Gangnam Severance Hospital, Anaesthesia and Pain Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.36"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000177102.11682.20"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666180-00005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/89.5.760"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.5.1430"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.5.1273"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes276"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2005.04121.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.5.659"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199907000-00018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31817aa6e4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu321"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","unstructured":"ChapmanB IrwinJ.Python as a First Programming Language for Biomedical Scientists.2015.","DOI":"10.25080\/Majora-7b98e3ed-002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.21"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3102\/10769986017001075"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.22237\/jmasm\/1509494760"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2006.09.004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00012"},{"key":"e_1_2_6_24_1","first-page":"6","article-title":"Postoperative nausea and vomiting in a gynecological and obstetrical population in South Eastern Nigeria","volume":"7","author":"Ugochukwu O","year":"2010","journal-title":"Pan African Medical Journal"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200206000-00054"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000180204.64588.EC"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318267ef31"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.14849","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:26:51Z","timestamp":1761672411000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/anae.14849"],"URL":"https:\/\/doi.org\/10.1111\/anae.14849","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"assertion":[{"value":"2019-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}