{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:37:44Z","timestamp":1781905064372,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","award":["NCT03808077"],"award-info":[{"award-number":["NCT03808077"]}],"id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Sugammadex is a novel reversal agent for aminosteroid neuromuscular blocking drugs, especially rocuronium. Given its renal excretion, sugammadex is not recommended for patients with end\u2010stage renal disease; however, reports exist of its use in this group of patients. This two\u2010institutional retrospective observational study aimed to review the safety profile and effectiveness of sugammadex in surgical patients with end\u2010stage renal disease who required pre\u2010operative renal replacement therapy. Adult surgical patients with end\u2010stage renal disease requiring pre\u2010operative renal replacement therapy, who received sugammadex between April 2016 and January 2019, were studied. The primary outcome was the incidence of postoperative tracheal re\u2010intubation within 48\u00a0h. The secondary outcome was the incidence of deferred tracheal extubation in the operating theatre. One hundred and fifty\u2010eight patients were identified from 125,653 surgical patients: 48 patients (30%) underwent renal transplantation and 110 (70%) underwent non\u2010renal transplantation procedures. There were 22 instances (14%) of deferred tracheal extubation due to surgical and\/or pre\u2010existing medical conditions. Out of the 136 patients who had the tracheal tube removed at the end of the procedure, three patients had their trachea re\u2010intubated within 48\u00a0h: two patients developed pulmonary oedema resulting from volume overload; and one patient had worsening sepsis. No incidence of recurrence of neuromuscular blockade was observed. Of note, 24 (18%) patients were found to have incomplete neuromuscular blockade reversal with neostigmine but administration of sugammadex led to successful tracheal extubation. In conclusion, sugammadex appears to be safe and effective in adult patients with end\u2010stage renal disease receiving pre\u2010operative renal replacement therapy.<\/jats:p>","DOI":"10.1111\/anae.14914","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T23:54:08Z","timestamp":1573602848000},"page":"348-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Short\u2010term safety and effectiveness of sugammadex for surgical patients with end\u2010stage renal disease: a two\u2010centre retrospective study"],"prefix":"10.1111","volume":"75","author":[{"given":"D. R.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Peri\u2010operative Medicine University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Tollinche","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Artman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Peri\u2010operative Medicine University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Peri\u2010operative Medicine University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. W.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Quinlan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Peri\u2010operative Medicine University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Peri\u2010operative Medicine University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-194207000-00006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020118)41:2<265::AID-ANIE265>3.0.CO;2-Q"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200309000-00018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200510000-00007"},{"key":"e_1_2_6_6_1","first-page":"CD012763","article-title":"Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults","volume":"8","author":"Hristovska AM","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_7_1","unstructured":"Food and Drug Administration: BRIDION\u00ae (sugammadex) Injection for intravenous use.Initial U.S. Approval: 2015. (Reference ID:3860969)2015.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/022225lbl.pdf(accessed 12\/05\/2019)."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes207"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000265152.78943.74"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen216"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep340"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet586"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000312"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002562"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.03.018"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.14914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.14914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:47:31Z","timestamp":1761670051000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.14914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/anae.14914"],"URL":"https:\/\/doi.org\/10.1111\/anae.14914","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736906215.793567917","asserted-by":"object"}]},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"2019-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}